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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & Afold [.zip] - may take several seconds...


Overview

Metric Multilign(20) Afold
MCC 0.865 > 0.569
Average MCC ± 95% Confidence Intervals 0.865 ± 0.040 > 0.564 ± 1.229
Sensitivity 0.763 > 0.500
Positive Predictive Value 0.983 > 0.655
Total TP 58 > 38
Total TN 8025 < 8026
Total FP 3 < 21
Total FP CONTRA 1 < 5
Total FP INCONS 0 < 15
Total FP COMP 2 > 1
Total FN 18 < 38
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Afold).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 58
Total TN 8025
Total FP 3
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 2
Total FN 18
Total Scores
MCC 0.865
Average MCC ± 95% Confidence Intervals 0.865 ± 0.040
Sensitivity 0.763
Positive Predictive Value 0.983
Nr of predictions 3

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.85 0.76 0.95 19 3301 1 1 0 0 6
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 2 0 0 2 6

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 38
Total TN 8026
Total FP 21
Total FP CONTRA 5
Total FP INCONS 15
Total FP COMP 1
Total FN 38
Total Scores
MCC 0.569
Average MCC ± 95% Confidence Intervals 0.564 ± 1.229
Sensitivity 0.500
Positive Predictive Value 0.655
Nr of predictions 3

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 5 14 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.82 0.71 0.94 17 2260 1 0 1 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.