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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(20) NanoFolder
MCC 0.865 > 0.144
Average MCC ± 95% Confidence Intervals 0.865 ± 0.204 > 0.145 ± 1.950
Sensitivity 0.769 > 0.173
Positive Predictive Value 0.976 > 0.134
Total TP 40 > 9
Total TN 5765 > 5739
Total FP 1 < 59
Total FP CONTRA 1 < 6
Total FP INCONS 0 < 52
Total FP COMP 0 < 1
Total FN 12 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 40
Total TN 5765
Total FP 1
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 0
Total FN 12
Total Scores
MCC 0.865
Average MCC ± 95% Confidence Intervals 0.865 ± 0.204
Sensitivity 0.769
Positive Predictive Value 0.976
Nr of predictions 2

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.85 0.76 0.95 19 3301 1 1 0 0 6
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 9
Total TN 5739
Total FP 59
Total FP CONTRA 6
Total FP INCONS 52
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.144
Average MCC ± 95% Confidence Intervals 0.145 ± 1.950
Sensitivity 0.173
Positive Predictive Value 0.134
Nr of predictions 2

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.