CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of RNAfold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & RNAfold [.zip] - may take several seconds...


Overview

Metric Murlet(20) RNAfold
MCC 0.741 > 0.702
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140 > 0.705 ± 0.378
Sensitivity 0.594 < 0.617
Positive Predictive Value 0.929 > 0.804
Total TP 79 < 82
Total TN 14648 > 14631
Total FP 8 < 22
Total FP CONTRA 0 < 6
Total FP INCONS 6 < 14
Total FP COMP 2 = 2
Total FN 54 > 51
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(20) and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNAfold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNAfold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNAfold).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 82
Total TN 14631
Total FP 22
Total FP CONTRA 6
Total FP INCONS 14
Total FP COMP 2
Total FN 51
Total Scores
MCC 0.702
Average MCC ± 95% Confidence Intervals 0.705 ± 0.378
Sensitivity 0.617
Positive Predictive Value 0.804
Nr of predictions 5

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.17 0.16 0.19 4 3300 17 6 11 0 21
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.75 0.65 0.88 22 4346 4 0 3 1 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.