CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of RNAshapes - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & RNAshapes [.zip] - may take several seconds...


Overview

Metric Murlet(20) RNAshapes
MCC 0.741 > 0.640
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140 > 0.658 ± 0.389
Sensitivity 0.594 > 0.571
Positive Predictive Value 0.929 > 0.724
Total TP 79 > 76
Total TN 14648 > 14628
Total FP 8 < 31
Total FP CONTRA 0 < 8
Total FP INCONS 6 < 21
Total FP COMP 2 = 2
Total FN 54 < 57
P-value 0.0

^top




Performance plots


  1. Comparison of performance of Murlet(20) and RNAshapes. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNAshapes).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNAshapes).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNAshapes. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNAshapes).

^top





Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

^top



2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

^top



Performance of RNAshapes - scored lower in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 76
Total TN 14628
Total FP 31
Total FP CONTRA 8
Total FP INCONS 21
Total FP COMP 2
Total FN 57
Total Scores
MCC 0.640
Average MCC ± 95% Confidence Intervals 0.658 ± 0.389
Sensitivity 0.571
Positive Predictive Value 0.724
Nr of predictions 5

^top



2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.17 0.16 0.19 4 3300 17 6 11 0 21
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.52 0.47 0.57 16 4343 13 2 10 1 18

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.