CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & RNAwolf [.zip] - may take several seconds...


Overview

Metric Murlet(20) RNAwolf
MCC 0.741 > 0.661
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140 > 0.706 ± 0.377
Sensitivity 0.594 < 0.647
Positive Predictive Value 0.929 > 0.683
Total TP 79 < 86
Total TN 14648 > 14607
Total FP 8 < 43
Total FP CONTRA 0 < 7
Total FP INCONS 6 < 33
Total FP COMP 2 < 3
Total FN 54 > 47
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(20) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 86
Total TN 14607
Total FP 43
Total FP CONTRA 7
Total FP INCONS 33
Total FP COMP 3
Total FN 47
Total Scores
MCC 0.661
Average MCC ± 95% Confidence Intervals 0.706 ± 0.377
Sensitivity 0.647
Positive Predictive Value 0.683
Nr of predictions 5

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.89 0.84 0.95 21 3299 2 1 0 1 4
PDB_00828 0.85 0.81 0.88 22 2460 3 1 2 0 5
PDB_00829 0.78 0.75 0.82 18 2256 4 1 3 0 6
PDB_01020 0.84 0.83 0.86 19 2256 5 1 2 2 4
PDB_01073 0.17 0.18 0.17 6 4336 29 3 26 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.