CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric NanoFolder Carnac(seed)
MCC 0.585 > 0.554
Average MCC ± 95% Confidence Intervals 0.583 ± 1.279 > 0.444 ± 0.960
Sensitivity 0.654 > 0.327
Positive Predictive Value 0.531 < 0.944
Total TP 34 > 17
Total TN 5921 < 5967
Total FP 40 > 1
Total FP CONTRA 10 > 1
Total FP INCONS 20 > 0
Total FP COMP 10 > 0
Total FN 18 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 5921
Total FP 40
Total FP CONTRA 10
Total FP INCONS 20
Total FP COMP 10
Total FN 18
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.583 ± 1.279
Sensitivity 0.654
Positive Predictive Value 0.531
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 17
Total TN 5967
Total FP 1
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 0
Total FN 35
Total Scores
MCC 0.554
Average MCC ± 95% Confidence Intervals 0.444 ± 0.960
Sensitivity 0.327
Positive Predictive Value 0.944
Nr of predictions 3

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00770 0.62 0.39 1.00 7 2009 0 0 0 0 11
RFA_00773 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00808 0.00 0.00 0.00 0 2016 0 0 0 0 16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.