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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric NanoFolder Mastr(seed)
MCC 0.489 > 0.343
Average MCC ± 95% Confidence Intervals 0.512 ± 0.706 > 0.327 ± 0.608
Sensitivity 0.544 > 0.241
Positive Predictive Value 0.448 < 0.500
Total TP 43 > 19
Total TN 8374 < 8432
Total FP 63 > 21
Total FP CONTRA 10 > 3
Total FP INCONS 43 > 16
Total FP COMP 10 > 2
Total FN 36 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Mastr(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Mastr(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 43
Total TN 8374
Total FP 63
Total FP CONTRA 10
Total FP INCONS 43
Total FP COMP 10
Total FN 36
Total Scores
MCC 0.489
Average MCC ± 95% Confidence Intervals 0.512 ± 0.706
Sensitivity 0.544
Positive Predictive Value 0.448
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 19
Total TN 8432
Total FP 21
Total FP CONTRA 3
Total FP INCONS 16
Total FP COMP 2
Total FN 60
Total Scores
MCC 0.343
Average MCC ± 95% Confidence Intervals 0.327 ± 0.608
Sensitivity 0.241
Positive Predictive Value 0.500
Nr of predictions 4

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.