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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & Afold [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) Afold
MCC 0.873 > 0.569
Average MCC ± 95% Confidence Intervals 0.873 ± 0.020 > 0.564 ± 1.229
Sensitivity 0.776 > 0.500
Positive Predictive Value 0.983 > 0.655
Total TP 59 > 38
Total TN 8024 < 8026
Total FP 5 < 21
Total FP CONTRA 1 < 5
Total FP INCONS 0 < 15
Total FP COMP 4 > 1
Total FN 17 < 38
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 59
Total TN 8024
Total FP 5
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 4
Total FN 17
Total Scores
MCC 0.873
Average MCC ± 95% Confidence Intervals 0.873 ± 0.020
Sensitivity 0.776
Positive Predictive Value 0.983
Nr of predictions 3

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.88 0.78 1.00 21 2464 2 0 0 2 6
PDB_00829 0.86 0.75 1.00 18 2260 2 0 0 2 6

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 38
Total TN 8026
Total FP 21
Total FP CONTRA 5
Total FP INCONS 15
Total FP COMP 1
Total FN 38
Total Scores
MCC 0.569
Average MCC ± 95% Confidence Intervals 0.564 ± 1.229
Sensitivity 0.500
Positive Predictive Value 0.655
Nr of predictions 3

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 5 14 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.82 0.71 0.94 17 2260 1 0 1 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.