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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Mastr(20)
MCC 0.835 > 0.561
Average MCC ± 95% Confidence Intervals 0.839 ± 0.049 > 0.572 ± 0.485
Sensitivity 0.774 > 0.459
Positive Predictive Value 0.904 > 0.693
Total TP 103 > 61
Total TN 14619 < 14645
Total FP 16 < 28
Total FP CONTRA 10 > 4
Total FP INCONS 1 < 23
Total FP COMP 5 > 1
Total FN 30 < 72
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 103
Total TN 14619
Total FP 16
Total FP CONTRA 10
Total FP INCONS 1
Total FP COMP 5
Total FN 30
Total Scores
MCC 0.835
Average MCC ± 95% Confidence Intervals 0.839 ± 0.049
Sensitivity 0.774
Positive Predictive Value 0.904
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.85 0.80 0.91 20 3299 2 2 0 0 5
PDB_00828 0.84 0.78 0.91 21 2462 3 2 0 1 6
PDB_00829 0.87 0.83 0.91 20 2256 3 2 0 1 4
PDB_01020 0.86 0.83 0.90 19 2257 4 2 0 2 4
PDB_01073 0.77 0.68 0.88 23 4345 4 2 1 1 11

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 61
Total TN 14645
Total FP 28
Total FP CONTRA 4
Total FP INCONS 23
Total FP COMP 1
Total FN 72
Total Scores
MCC 0.561
Average MCC ± 95% Confidence Intervals 0.572 ± 0.485
Sensitivity 0.459
Positive Predictive Value 0.693
Nr of predictions 5

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 3 16 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.84 0.71 1.00 17 2261 0 0 0 0 7
PDB_01020 0.81 0.65 1.00 15 2263 0 0 0 0 8
PDB_01073 0.34 0.24 0.50 8 4355 8 1 7 0 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.