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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) NanoFolder
MCC 0.783 > 0.346
Average MCC ± 95% Confidence Intervals 0.764 ± 0.133 > 0.385 ± 0.426
Sensitivity 0.712 > 0.400
Positive Predictive Value 0.864 > 0.311
Total TP 89 > 50
Total TN 14173 > 14115
Total FP 17 < 124
Total FP CONTRA 11 < 19
Total FP INCONS 3 < 92
Total FP COMP 3 < 13
Total FN 36 < 75
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and NanoFolder).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 89
Total TN 14173
Total FP 17
Total FP CONTRA 11
Total FP INCONS 3
Total FP COMP 3
Total FN 36
Total Scores
MCC 0.783
Average MCC ± 95% Confidence Intervals 0.764 ± 0.133
Sensitivity 0.712
Positive Predictive Value 0.864
Nr of predictions 6

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.85 0.80 0.91 20 3299 2 2 0 0 5
PDB_00828 0.84 0.78 0.91 21 2462 3 2 0 1 6
PDB_01009 0.93 0.90 0.95 19 2465 3 0 1 2 2
RFA_00770 0.63 0.56 0.71 10 2002 4 3 1 0 8
RFA_00773 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00808 0.71 0.56 0.90 9 2006 1 1 0 0 7

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 50
Total TN 14115
Total FP 124
Total FP CONTRA 19
Total FP INCONS 92
Total FP COMP 13
Total FN 75
Total Scores
MCC 0.346
Average MCC ± 95% Confidence Intervals 0.385 ± 0.426
Sensitivity 0.400
Positive Predictive Value 0.311
Nr of predictions 6

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.