CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	PknotsRG		Carnac(seed)
MCC	0.819	>	0.582
Average MCC ± 95% Confidence Intervals	0.854 ± 0.166	>	0.456 ± 0.229
Sensitivity	0.818	>	0.354
Positive Predictive Value	0.823	<	0.962
Total TP	233	>	101
Total TN	37435	<	37613
Total FP	71	>	5
Total FP CONTRA	9	>	3
Total FP INCONS	41	>	1
Total FP COMP	21	>	1
Total FN	52	<	184
P-value	1.34193807955e-08

Comparison of performance of PknotsRG and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and Carnac(seed)).

Total Scores
MCC	0.819
Average MCC ± 95% Confidence Intervals	0.854 ± 0.166
Sensitivity	0.818
Positive Predictive Value	0.823
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	1.00	1.00	1.00	14	932	0	0	0	0	0
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2675	27	1	25	1	23
PDB_01092	glmS links to Rfam database...	0.71	0.67	0.74	35	10106	13	2	10	1	17
RFA_00632	HDV_ribozyme links to Rfam database...	0.88	0.89	0.86	25	4066	6	2	2	2	3
RFA_00636	HDV_ribozyme links to Rfam database...	0.95	0.96	0.93	27	3976	4	2	0	2	1
RFA_00767	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	3	0	0	3	0
RFA_00768	Corona_pk3 links to Rfam database...	1.00	1.00	1.00	18	1873	2	0	0	2	0
RFA_00769	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	3	1	0	2	0
RFA_00770	Corona_pk3 links to Rfam database...	0.88	0.78	1.00	14	2002	3	0	0	3	4
RFA_00773	Corona_pk3 links to Rfam database...	0.97	1.00	0.95	18	1934	4	1	0	3	0
RFA_00779	Corona_pk3 links to Rfam database...	0.97	0.94	1.00	17	1936	2	0	0	2	1
RFA_00808	RydC links to Rfam database...	1.00	1.00	1.00	16	2000	0	0	0	0	0
RFA_00809	RydC links to Rfam database...	0.79	0.81	0.76	13	2128	4	0	4	0	3

Total Scores
MCC	0.582
Average MCC ± 95% Confidence Intervals	0.456 ± 0.229
Sensitivity	0.354
Positive Predictive Value	0.962
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.88	0.79	1.00	11	935	0	0	0	0	3
PDB_00716	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	23
PDB_01092	glmS links to Rfam database...	0.77	0.63	0.94	33	10118	3	1	1	1	19
RFA_00632	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4095	0	0	0	0	28
RFA_00636	HDV_ribozyme links to Rfam database...	0.00	0.00	0.00	0	4005	0	0	0	0	28
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.62	0.39	1.00	7	2009	0	0	0	0	11
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	1	0	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1943	0	0	0	0	8
RFA_00808	RydC links to Rfam database...	0.00	0.00	0.00	0	2016	0	0	0	0	16
RFA_00809	RydC links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	16

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.