CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNASLOpt Mastr(seed)
MCC 0.635 > 0.341
Average MCC ± 95% Confidence Intervals 0.635 ± 0.113 > 0.295 ± 0.170
Sensitivity 0.565 > 0.176
Positive Predictive Value 0.718 > 0.670
Total TP 222 > 69
Total TN 48821 < 49027
Total FP 92 > 37
Total FP CONTRA 9 > 5
Total FP INCONS 78 > 29
Total FP COMP 5 > 3
Total FN 171 < 324
P-value 1.75835195567e-08

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Performance plots


  1. Comparison of performance of RNASLOpt and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 222
Total TN 48821
Total FP 92
Total FP CONTRA 9
Total FP INCONS 78
Total FP COMP 5
Total FN 171
Total Scores
MCC 0.635
Average MCC ± 95% Confidence Intervals 0.635 ± 0.113
Sensitivity 0.565
Positive Predictive Value 0.718
Nr of predictions 17

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2680 22 0 21 1 23
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.56 0.47 0.67 16 4347 9 0 8 1 18
PDB_01092 0.74 0.63 0.87 33 10115 7 1 4 2 19
RFA_00632 0.59 0.57 0.62 16 4069 10 2 8 0 12
RFA_00636 0.65 0.64 0.67 18 3978 9 2 7 0 10
RFA_00767 0.63 0.56 0.71 10 1877 4 0 4 0 8
RFA_00768 0.61 0.56 0.67 10 1876 5 0 5 0 8
RFA_00769 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00770 0.47 0.39 0.58 7 2004 5 1 4 0 11
RFA_00773 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00779 0.74 0.56 1.00 10 1943 0 0 0 0 8
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.