CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of ContextFold - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & ContextFold [.zip] - may take several seconds...


Overview

Metric RNASampler(20) ContextFold
MCC 0.840 > 0.759
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055 > 0.783 ± 0.209
Sensitivity 0.714 > 0.669
Positive Predictive Value 0.990 > 0.864
Total TP 95 > 89
Total TN 14637 > 14630
Total FP 3 < 15
Total FP CONTRA 1 < 3
Total FP INCONS 0 < 11
Total FP COMP 2 > 1
Total FN 38 < 44
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and ContextFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and ContextFold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and ContextFold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and ContextFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and ContextFold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 95
Total TN 14637
Total FP 3
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 2
Total FN 38
Total Scores
MCC 0.840
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055
Sensitivity 0.714
Positive Predictive Value 0.990
Nr of predictions 5

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.77 0.59 1.00 20 4351 1 0 0 1 14

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Performance of ContextFold - scored lower in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 89
Total TN 14630
Total FP 15
Total FP CONTRA 3
Total FP INCONS 11
Total FP COMP 1
Total FN 44
Total Scores
MCC 0.759
Average MCC ± 95% Confidence Intervals 0.783 ± 0.209
Sensitivity 0.669
Positive Predictive Value 0.864
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.85 0.76 0.95 19 3301 1 1 0 0 6
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.48 0.44 0.54 15 4343 13 2 11 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.