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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Murlet(20)
MCC 0.840 > 0.741
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055 > 0.748 ± 0.140
Sensitivity 0.714 > 0.594
Positive Predictive Value 0.990 > 0.929
Total TP 95 > 79
Total TN 14637 < 14648
Total FP 3 < 8
Total FP CONTRA 1 > 0
Total FP INCONS 0 < 6
Total FP COMP 2 = 2
Total FN 38 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Murlet(20)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 95
Total TN 14637
Total FP 3
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 2
Total FN 38
Total Scores
MCC 0.840
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055
Sensitivity 0.714
Positive Predictive Value 0.990
Nr of predictions 5

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.77 0.59 1.00 20 4351 1 0 0 1 14

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.