CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) RSpredict(seed)
MCC 0.832 > 0.602
Average MCC ± 95% Confidence Intervals 0.837 ± 0.076 > 0.607 ± 0.279
Sensitivity 0.694 > 0.435
Positive Predictive Value 1.000 > 0.839
Total TP 75 > 47
Total TN 11337 < 11356
Total FP 2 < 9
Total FP CONTRA 0 < 6
Total FP INCONS 0 < 3
Total FP COMP 2 > 0
Total FN 33 < 61
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 75
Total TN 11337
Total FP 2
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 2
Total FN 33
Total Scores
MCC 0.832
Average MCC ± 95% Confidence Intervals 0.837 ± 0.076
Sensitivity 0.694
Positive Predictive Value 1.000
Nr of predictions 4

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.77 0.59 1.00 20 4351 1 0 0 1 14

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 47
Total TN 11356
Total FP 9
Total FP CONTRA 6
Total FP INCONS 3
Total FP COMP 0
Total FN 61
Total Scores
MCC 0.602
Average MCC ± 95% Confidence Intervals 0.607 ± 0.279
Sensitivity 0.435
Positive Predictive Value 0.839
Nr of predictions 4

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
PDB_00829 0.74 0.63 0.88 15 2261 2 2 0 0 9
PDB_01020 0.76 0.65 0.88 15 2261 2 2 0 0 8
PDB_01073 0.39 0.18 0.86 6 4364 1 0 1 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.