CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Vsfold5 [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Vsfold5
MCC 0.840 > 0.774
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055 > 0.786 ± 0.161
Sensitivity 0.714 > 0.699
Positive Predictive Value 0.990 > 0.861
Total TP 95 > 93
Total TN 14637 > 14625
Total FP 3 < 17
Total FP CONTRA 1 < 6
Total FP INCONS 0 < 9
Total FP COMP 2 = 2
Total FN 38 < 40
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 95
Total TN 14637
Total FP 3
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 2
Total FN 38
Total Scores
MCC 0.840
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055
Sensitivity 0.714
Positive Predictive Value 0.990
Nr of predictions 5

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.77 0.59 1.00 20 4351 1 0 0 1 14

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 93
Total TN 14625
Total FP 17
Total FP CONTRA 6
Total FP INCONS 9
Total FP COMP 2
Total FN 40
Total Scores
MCC 0.774
Average MCC ± 95% Confidence Intervals 0.786 ± 0.161
Sensitivity 0.699
Positive Predictive Value 0.861
Nr of predictions 5

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.83 0.79 0.86 19 2256 3 2 1 0 5
PDB_01020 0.82 0.78 0.86 18 2257 4 2 1 1 5
PDB_01073 0.56 0.47 0.67 16 4347 9 1 7 1 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.