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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) NanoFolder
MCC 0.687 > 0.489
Average MCC ± 95% Confidence Intervals 0.689 ± 0.075 > 0.512 ± 0.706
Sensitivity 0.570 > 0.544
Positive Predictive Value 0.833 > 0.448
Total TP 45 > 43
Total TN 8416 > 8374
Total FP 9 < 63
Total FP CONTRA 2 < 10
Total FP INCONS 7 < 43
Total FP COMP 0 < 10
Total FN 34 < 36
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 45
Total TN 8416
Total FP 9
Total FP CONTRA 2
Total FP INCONS 7
Total FP COMP 0
Total FN 34
Total Scores
MCC 0.687
Average MCC ± 95% Confidence Intervals 0.689 ± 0.075
Sensitivity 0.570
Positive Predictive Value 0.833
Nr of predictions 4

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.70 0.59 0.84 16 2466 3 2 1 0 11
RFA_00770 0.65 0.56 0.77 10 2003 3 0 3 0 8
RFA_00773 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 43
Total TN 8374
Total FP 63
Total FP CONTRA 10
Total FP INCONS 43
Total FP COMP 10
Total FN 36
Total Scores
MCC 0.489
Average MCC ± 95% Confidence Intervals 0.512 ± 0.706
Sensitivity 0.544
Positive Predictive Value 0.448
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.