CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNAsubopt Mastr(seed)
MCC 0.538 > 0.341
Average MCC ± 95% Confidence Intervals 0.542 ± 0.140 > 0.295 ± 0.170
Sensitivity 0.506 > 0.176
Positive Predictive Value 0.578 < 0.670
Total TP 199 > 69
Total TN 48786 < 49027
Total FP 159 > 37
Total FP CONTRA 22 > 5
Total FP INCONS 123 > 29
Total FP COMP 14 > 3
Total FN 194 < 324
P-value 2.59578924681e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Mastr(seed)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 199
Total TN 48786
Total FP 159
Total FP CONTRA 22
Total FP INCONS 123
Total FP COMP 14
Total FN 194
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.542 ± 0.140
Sensitivity 0.506
Positive Predictive Value 0.578
Nr of predictions 17

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.52 0.47 0.57 16 4343 13 2 10 1 18
PDB_01092 0.66 0.60 0.74 31 10111 13 3 8 2 21
RFA_00632 0.31 0.32 0.30 9 4065 21 2 19 0 19
RFA_00636 0.42 0.43 0.43 12 3977 16 2 14 0 16
RFA_00767 0.63 0.56 0.71 10 1877 4 0 4 0 8
RFA_00768 0.48 0.44 0.53 8 1876 7 1 6 0 10
RFA_00769 0.52 0.56 0.50 10 1933 10 4 6 0 8
RFA_00770 0.61 0.56 0.67 10 2001 8 0 5 3 8
RFA_00773 0.68 0.56 0.83 10 1941 5 1 1 3 8
RFA_00779 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 18 2 13 3 16
RFA_00809 0.36 0.38 0.35 6 2128 11 1 10 0 10

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.