CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAwolf - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAwolf & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNAwolf Mastr(seed)
MCC 0.487 > 0.341
Average MCC ± 95% Confidence Intervals 0.502 ± 0.103 > 0.295 ± 0.170
Sensitivity 0.461 > 0.176
Positive Predictive Value 0.523 < 0.670
Total TP 181 > 69
Total TN 48784 < 49027
Total FP 189 > 37
Total FP CONTRA 26 > 5
Total FP INCONS 139 > 29
Total FP COMP 24 > 3
Total FN 212 < 324
P-value 3.39090039918e-08

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Performance plots


  1. Comparison of performance of RNAwolf and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAwolf and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAwolf and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAwolf and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAwolf and Mastr(seed)).

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Performance of RNAwolf - scored higher in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 181
Total TN 48784
Total FP 189
Total FP CONTRA 26
Total FP INCONS 139
Total FP COMP 24
Total FN 212
Total Scores
MCC 0.487
Average MCC ± 95% Confidence Intervals 0.502 ± 0.103
Sensitivity 0.461
Positive Predictive Value 0.523
Nr of predictions 17

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.42 0.36 0.50 5 936 6 0 5 1 9
PDB_00716 0.68 0.57 0.81 13 2685 3 0 3 0 10
PDB_00828 0.85 0.81 0.88 22 2460 3 1 2 0 5
PDB_00829 0.78 0.75 0.82 18 2256 4 1 3 0 6
PDB_01020 0.84 0.83 0.86 19 2256 5 1 2 2 4
PDB_01073 0.17 0.18 0.17 6 4336 29 3 26 0 28
PDB_01092 0.43 0.38 0.49 20 10112 23 2 19 2 32
RFA_00632 0.25 0.25 0.27 7 4069 22 1 18 3 21
RFA_00636 0.40 0.39 0.41 11 3978 19 1 15 3 17
RFA_00767 0.48 0.44 0.53 8 1876 8 1 6 1 10
RFA_00768 0.50 0.44 0.57 8 1877 8 1 5 2 10
RFA_00769 0.41 0.44 0.38 8 1932 13 3 10 0 10
RFA_00770 0.51 0.50 0.53 9 1999 12 2 6 4 9
RFA_00773 0.42 0.39 0.47 7 1938 12 1 7 4 11
RFA_00779 0.26 0.28 0.26 5 1934 14 6 8 0 13
RFA_00808 0.68 0.56 0.82 9 2005 2 2 0 0 7
RFA_00809 0.47 0.38 0.60 6 2135 6 0 4 2 10

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.