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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric RSpredict(20) Mastr(20)
MCC 0.672 > 0.561
Average MCC ± 95% Confidence Intervals 0.671 ± 0.248 > 0.572 ± 0.485
Sensitivity 0.549 > 0.459
Positive Predictive Value 0.830 > 0.693
Total TP 73 > 61
Total TN 14645 = 14645
Total FP 17 < 28
Total FP CONTRA 6 > 4
Total FP INCONS 9 < 23
Total FP COMP 2 > 1
Total FN 60 < 72
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(20) and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and Mastr(20)).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 73
Total TN 14645
Total FP 17
Total FP CONTRA 6
Total FP INCONS 9
Total FP COMP 2
Total FN 60
Total Scores
MCC 0.672
Average MCC ± 95% Confidence Intervals 0.671 ± 0.248
Sensitivity 0.549
Positive Predictive Value 0.830
Nr of predictions 5

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.66 0.56 0.78 14 3303 5 0 4 1 11
PDB_00828 0.82 0.74 0.91 20 2463 2 2 0 0 7
PDB_00829 0.70 0.63 0.79 15 2259 4 2 2 0 9
PDB_01020 0.84 0.78 0.90 18 2258 3 2 0 1 5
PDB_01073 0.34 0.18 0.67 6 4362 3 0 3 0 28

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 61
Total TN 14645
Total FP 28
Total FP CONTRA 4
Total FP INCONS 23
Total FP COMP 1
Total FN 72
Total Scores
MCC 0.561
Average MCC ± 95% Confidence Intervals 0.572 ± 0.485
Sensitivity 0.459
Positive Predictive Value 0.693
Nr of predictions 5

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 3 16 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.84 0.71 1.00 17 2261 0 0 0 0 7
PDB_01020 0.81 0.65 1.00 15 2263 0 0 0 0 8
PDB_01073 0.34 0.24 0.50 8 4355 8 1 7 0 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.