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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric RSpredict(20) RSpredict(seed)
MCC 0.676 > 0.602
Average MCC ± 95% Confidence Intervals 0.674 ± 0.367 > 0.607 ± 0.279
Sensitivity 0.546 > 0.435
Positive Predictive Value 0.843 > 0.839
Total TP 59 > 47
Total TN 11342 < 11356
Total FP 12 > 9
Total FP CONTRA 6 = 6
Total FP INCONS 5 > 3
Total FP COMP 1 > 0
Total FN 49 < 61
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and RSpredict(seed)).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 59
Total TN 11342
Total FP 12
Total FP CONTRA 6
Total FP INCONS 5
Total FP COMP 1
Total FN 49
Total Scores
MCC 0.676
Average MCC ± 95% Confidence Intervals 0.674 ± 0.367
Sensitivity 0.546
Positive Predictive Value 0.843
Nr of predictions 4

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.82 0.74 0.91 20 2463 2 2 0 0 7
PDB_00829 0.70 0.63 0.79 15 2259 4 2 2 0 9
PDB_01020 0.84 0.78 0.90 18 2258 3 2 0 1 5
PDB_01073 0.34 0.18 0.67 6 4362 3 0 3 0 28

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 47
Total TN 11356
Total FP 9
Total FP CONTRA 6
Total FP INCONS 3
Total FP COMP 0
Total FN 61
Total Scores
MCC 0.602
Average MCC ± 95% Confidence Intervals 0.607 ± 0.279
Sensitivity 0.435
Positive Predictive Value 0.839
Nr of predictions 4

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
PDB_00829 0.74 0.63 0.88 15 2261 2 2 0 0 9
PDB_01020 0.76 0.65 0.88 15 2261 2 2 0 0 8
PDB_01073 0.39 0.18 0.86 6 4364 1 0 1 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.