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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RSpredict(seed) Mastr(seed)
MCC 0.514 > 0.341
Average MCC ± 95% Confidence Intervals 0.515 ± 0.084 > 0.295 ± 0.170
Sensitivity 0.427 > 0.176
Positive Predictive Value 0.625 < 0.670
Total TP 168 > 69
Total TN 48861 < 49027
Total FP 105 > 37
Total FP CONTRA 41 > 5
Total FP INCONS 60 > 29
Total FP COMP 4 > 3
Total FN 225 < 324
P-value 2.36983135185e-08

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Performance plots


  1. Comparison of performance of RSpredict(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 168
Total TN 48861
Total FP 105
Total FP CONTRA 41
Total FP INCONS 60
Total FP COMP 4
Total FN 225
Total Scores
MCC 0.514
Average MCC ± 95% Confidence Intervals 0.515 ± 0.084
Sensitivity 0.427
Positive Predictive Value 0.625
Nr of predictions 17

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.71 0.57 0.89 8 937 1 0 1 0 6
PDB_00716 0.59 0.48 0.73 11 2686 4 0 4 0 12
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
PDB_00829 0.74 0.63 0.88 15 2261 2 2 0 0 9
PDB_01020 0.76 0.65 0.88 15 2261 2 2 0 0 8
PDB_01073 0.39 0.18 0.86 6 4364 1 0 1 0 28
PDB_01092 0.48 0.37 0.63 19 10123 13 1 10 2 33
RFA_00632 0.47 0.39 0.58 11 4076 8 3 5 0 17
RFA_00636 0.62 0.54 0.71 15 3984 6 3 3 0 13
RFA_00767 0.19 0.17 0.23 3 1878 10 3 7 0 15
RFA_00768 0.19 0.17 0.23 3 1878 10 3 7 0 15
RFA_00769 0.59 0.56 0.63 10 1937 6 4 2 0 8
RFA_00770 0.54 0.56 0.53 10 1997 9 6 3 0 8
RFA_00773 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00779 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00808 0.60 0.50 0.73 8 2005 4 0 3 1 8
RFA_00809 0.37 0.31 0.45 5 2134 7 0 6 1 11

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.