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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RSpredict(seed) NanoFolder
MCC 0.535 > 0.489
Average MCC ± 95% Confidence Intervals 0.544 ± 0.069 > 0.512 ± 0.706
Sensitivity 0.481 < 0.544
Positive Predictive Value 0.603 > 0.448
Total TP 38 < 43
Total TN 8407 > 8374
Total FP 26 < 63
Total FP CONTRA 14 > 10
Total FP INCONS 11 < 43
Total FP COMP 1 < 10
Total FN 41 > 36
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and NanoFolder).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 38
Total TN 8407
Total FP 26
Total FP CONTRA 14
Total FP INCONS 11
Total FP COMP 1
Total FN 41
Total Scores
MCC 0.535
Average MCC ± 95% Confidence Intervals 0.544 ± 0.069
Sensitivity 0.481
Positive Predictive Value 0.603
Nr of predictions 4

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
RFA_00770 0.54 0.56 0.53 10 1997 9 6 3 0 8
RFA_00773 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00808 0.60 0.50 0.73 8 2005 4 0 3 1 8

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 43
Total TN 8374
Total FP 63
Total FP CONTRA 10
Total FP INCONS 43
Total FP COMP 10
Total FN 36
Total Scores
MCC 0.489
Average MCC ± 95% Confidence Intervals 0.512 ± 0.706
Sensitivity 0.544
Positive Predictive Value 0.448
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.