CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Mastr(20) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Mastr(20)
MCC 0.784 > 0.561
Average MCC ± 95% Confidence Intervals 0.800 ± 0.177 > 0.572 ± 0.485
Sensitivity 0.684 > 0.459
Positive Predictive Value 0.901 > 0.693
Total TP 91 > 61
Total TN 14632 < 14645
Total FP 12 < 28
Total FP CONTRA 1 < 4
Total FP INCONS 9 < 23
Total FP COMP 2 > 1
Total FN 42 < 72
P-value 0.0

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Performance plots


  1. Comparison of performance of Vsfold4 and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Mastr(20)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 91
Total TN 14632
Total FP 12
Total FP CONTRA 1
Total FP INCONS 9
Total FP COMP 2
Total FN 42
Total Scores
MCC 0.784
Average MCC ± 95% Confidence Intervals 0.800 ± 0.177
Sensitivity 0.684
Positive Predictive Value 0.901
Nr of predictions 5

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.55 0.47 0.64 16 4346 10 0 9 1 18

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 61
Total TN 14645
Total FP 28
Total FP CONTRA 4
Total FP INCONS 23
Total FP COMP 1
Total FN 72
Total Scores
MCC 0.561
Average MCC ± 95% Confidence Intervals 0.572 ± 0.485
Sensitivity 0.459
Positive Predictive Value 0.693
Nr of predictions 5

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 -0.01 0.00 0.00 0 3302 20 3 16 1 25
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00829 0.84 0.71 1.00 17 2261 0 0 0 0 7
PDB_01020 0.81 0.65 1.00 15 2263 0 0 0 0 8
PDB_01073 0.34 0.24 0.50 8 4355 8 1 7 0 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.