CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Mastr(seed)
MCC 0.488 > 0.341
Average MCC ± 95% Confidence Intervals 0.463 ± 0.169 > 0.295 ± 0.170
Sensitivity 0.445 > 0.176
Positive Predictive Value 0.543 < 0.670
Total TP 175 > 69
Total TN 48808 < 49027
Total FP 155 > 37
Total FP CONTRA 21 > 5
Total FP INCONS 126 > 29
Total FP COMP 8 > 3
Total FN 218 < 324
P-value 2.91763127434e-08

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Performance plots


  1. Comparison of performance of Vsfold4 and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Mastr(seed)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 175
Total TN 48808
Total FP 155
Total FP CONTRA 21
Total FP INCONS 126
Total FP COMP 8
Total FN 218
Total Scores
MCC 0.488
Average MCC ± 95% Confidence Intervals 0.463 ± 0.169
Sensitivity 0.445
Positive Predictive Value 0.543
Nr of predictions 17

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.84 0.71 1.00 10 936 0 0 0 0 4
PDB_00716 0.17 0.17 0.18 4 2679 19 0 18 1 19
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.55 0.47 0.64 16 4346 10 0 9 1 18
PDB_01092 0.66 0.58 0.77 30 10114 10 2 7 1 22
RFA_00632 0.36 0.36 0.37 10 4068 17 3 14 0 18
RFA_00636 0.58 0.57 0.59 16 3978 11 1 10 0 12
RFA_00767 -0.01 0.00 0.00 0 1878 13 1 12 0 18
RFA_00768 -0.01 0.00 0.00 0 1875 16 1 15 0 18
RFA_00769 0.50 0.50 0.50 9 1935 9 4 5 0 9
RFA_00770 -0.01 0.00 0.00 0 2003 15 2 11 2 18
RFA_00773 -0.01 0.00 0.00 0 1936 19 1 16 2 18
RFA_00779 0.65 0.56 0.77 10 1940 3 2 1 0 8
RFA_00808 0.62 0.56 0.69 9 2003 4 3 1 0 7
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 69
Total TN 49027
Total FP 37
Total FP CONTRA 5
Total FP INCONS 29
Total FP COMP 3
Total FN 324
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.295 ± 0.170
Sensitivity 0.176
Positive Predictive Value 0.670
Nr of predictions 17

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00828 0.00 0.00 0.00 0 2485 0 0 0 0 27
PDB_00829 0.00 0.00 0.00 0 2278 0 0 0 0 24
PDB_01020 0.00 0.00 0.00 0 2278 0 0 0 0 23
PDB_01073 0.00 0.00 0.00 0 4371 0 0 0 0 34
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00767 0.67 0.50 0.90 9 1881 1 0 1 0 9
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.