CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Murlet(20) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Murlet(20)
MCC 0.784 > 0.741
Average MCC ± 95% Confidence Intervals 0.800 ± 0.177 > 0.748 ± 0.140
Sensitivity 0.684 > 0.594
Positive Predictive Value 0.901 < 0.929
Total TP 91 > 79
Total TN 14632 < 14648
Total FP 12 > 8
Total FP CONTRA 1 > 0
Total FP INCONS 9 > 6
Total FP COMP 2 = 2
Total FN 42 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of Vsfold4 and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Murlet(20)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 91
Total TN 14632
Total FP 12
Total FP CONTRA 1
Total FP INCONS 9
Total FP COMP 2
Total FN 42
Total Scores
MCC 0.784
Average MCC ± 95% Confidence Intervals 0.800 ± 0.177
Sensitivity 0.684
Positive Predictive Value 0.901
Nr of predictions 5

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.55 0.47 0.64 16 4346 10 0 9 1 18

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 79
Total TN 14648
Total FP 8
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.748 ± 0.140
Sensitivity 0.594
Positive Predictive Value 0.929
Nr of predictions 5

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_00829 0.82 0.67 1.00 16 2262 0 0 0 0 8
PDB_01020 0.83 0.70 1.00 16 2262 0 0 0 0 7
PDB_01073 0.66 0.44 1.00 15 4356 1 0 0 1 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.