CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 RSpredict(seed)
MCC 0.531 > 0.514
Average MCC ± 95% Confidence Intervals 0.517 ± 0.170 > 0.515 ± 0.084
Sensitivity 0.501 > 0.427
Positive Predictive Value 0.569 < 0.625
Total TP 197 > 168
Total TN 48784 < 48861
Total FP 155 > 105
Total FP CONTRA 24 < 41
Total FP INCONS 125 > 60
Total FP COMP 6 > 4
Total FN 196 < 225
P-value 4.9656853596e-05

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Performance plots


  1. Comparison of performance of Vsfold5 and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and RSpredict(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and RSpredict(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and RSpredict(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 197
Total TN 48784
Total FP 155
Total FP CONTRA 24
Total FP INCONS 125
Total FP COMP 6
Total FN 196
Total Scores
MCC 0.531
Average MCC ± 95% Confidence Intervals 0.517 ± 0.170
Sensitivity 0.501
Positive Predictive Value 0.569
Nr of predictions 17

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.78 0.79 0.79 11 932 3 1 2 0 3
PDB_00716 0.17 0.17 0.18 4 2679 19 0 18 1 19
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.83 0.79 0.86 19 2256 3 2 1 0 5
PDB_01020 0.82 0.78 0.86 18 2257 4 2 1 1 5
PDB_01073 0.56 0.47 0.67 16 4347 9 1 7 1 18
PDB_01092 0.73 0.69 0.77 36 10106 12 2 9 1 16
RFA_00632 -0.01 0.00 0.00 0 4073 22 0 22 0 28
RFA_00636 0.58 0.57 0.59 16 3978 11 1 10 0 12
RFA_00767 0.21 0.22 0.22 4 1873 14 2 12 0 14
RFA_00768 -0.01 0.00 0.00 0 1875 16 1 15 0 18
RFA_00769 0.50 0.50 0.50 9 1935 9 4 5 0 9
RFA_00770 0.65 0.56 0.77 10 2003 3 3 0 0 8
RFA_00773 -0.01 0.00 0.00 0 1936 19 1 16 2 18
RFA_00779 0.69 0.61 0.79 11 1939 3 3 0 0 7
RFA_00808 1.00 1.00 1.00 16 2000 0 0 0 0 0
RFA_00809 0.45 0.44 0.47 7 2130 8 1 7 0 9

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 168
Total TN 48861
Total FP 105
Total FP CONTRA 41
Total FP INCONS 60
Total FP COMP 4
Total FN 225
Total Scores
MCC 0.514
Average MCC ± 95% Confidence Intervals 0.515 ± 0.084
Sensitivity 0.427
Positive Predictive Value 0.625
Nr of predictions 17

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.71 0.57 0.89 8 937 1 0 1 0 6
PDB_00716 0.59 0.48 0.73 11 2686 4 0 4 0 12
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
PDB_00829 0.74 0.63 0.88 15 2261 2 2 0 0 9
PDB_01020 0.76 0.65 0.88 15 2261 2 2 0 0 8
PDB_01073 0.39 0.18 0.86 6 4364 1 0 1 0 28
PDB_01092 0.48 0.37 0.63 19 10123 13 1 10 2 33
RFA_00632 0.47 0.39 0.58 11 4076 8 3 5 0 17
RFA_00636 0.62 0.54 0.71 15 3984 6 3 3 0 13
RFA_00767 0.19 0.17 0.23 3 1878 10 3 7 0 15
RFA_00768 0.19 0.17 0.23 3 1878 10 3 7 0 15
RFA_00769 0.59 0.56 0.63 10 1937 6 4 2 0 8
RFA_00770 0.54 0.56 0.53 10 1997 9 6 3 0 8
RFA_00773 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00779 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00808 0.60 0.50 0.73 8 2005 4 0 3 1 8
RFA_00809 0.37 0.31 0.45 5 2134 7 0 6 1 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.