CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Afold		CMfinder(seed)
MCC	0.534	>	0.346
Average MCC ± 95% Confidence Intervals	0.521 ± 0.121	>	0.354 ± 0.071
Sensitivity	0.528	>	0.160
Positive Predictive Value	0.543	<	0.753
Total TP	694	>	210
Total TN	914471	<	915471
Total FP	755	>	76
Total FP CONTRA	118	>	3
Total FP INCONS	467	>	66
Total FP COMP	170	>	7
Total FN	621	<	1105
P-value	1.5677163434e-08

Comparison of performance of Afold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and CMfinder(seed)).

Total Scores
MCC	0.534
Average MCC ± 95% Confidence Intervals	0.521 ± 0.121
Sensitivity	0.528
Positive Predictive Value	0.543
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.22	0.22	0.22	25	103625	113	13	77	23	90
CRW_00016	Intron_gpI links to Rfam database...	0.65	0.62	0.69	74	77313	47	5	29	13	46
CRW_00610	Intron_gpI links to Rfam database...	0.42	0.42	0.43	34	36235	46	6	40	0	47
CRW_00613	Intron_gpI links to Rfam database...	0.46	0.42	0.51	33	34915	41	2	30	9	45
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	141	24	53	64	52
CRW_00633	Intron_gpI links to Rfam database...	0.45	0.44	0.47	47	63445	58	10	44	4	59
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.74	0.81	89	70015	26	0	21	5	31
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.64	0.68	75	62725	41	8	27	6	42
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.73	0.74	81	72281	36	10	18	8	30
CRW_00674	Intron_gpI links to Rfam database...	0.55	0.55	0.55	68	83312	61	8	48	5	56
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	75	17	41	17	51
CRW_00692	Intron_gpI links to Rfam database...	0.57	0.57	0.57	51	68545	54	15	24	15	39
PDB_00827	Intron_gpI links to Rfam database...	0.67	0.59	0.76	48	26965	16	0	15	1	33

Total Scores
MCC	0.346
Average MCC ± 95% Confidence Intervals	0.354 ± 0.071
Sensitivity	0.160
Positive Predictive Value	0.753
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.