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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & Cylofold [.zip] - may take several seconds...


Overview

Metric Afold Cylofold
MCC 0.460 > 0.271
Average MCC ± 95% Confidence Intervals 0.460 ± 0.317 > 0.275 ± 1.303
Sensitivity 0.460 > 0.241
Positive Predictive Value 0.463 > 0.308
Total TP 63 > 33
Total TN 60452 < 60481
Total FP 81 > 78
Total FP CONTRA 10 > 3
Total FP INCONS 63 < 71
Total FP COMP 8 > 4
Total FN 74 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and Cylofold).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 63
Total TN 60452
Total FP 81
Total FP CONTRA 10
Total FP INCONS 63
Total FP COMP 8
Total FN 74
Total Scores
MCC 0.460
Average MCC ± 95% Confidence Intervals 0.460 ± 0.317
Sensitivity 0.460
Positive Predictive Value 0.463
Nr of predictions 2

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.48 0.48 0.49 34 32316 41 2 33 6 37
ASE_00429 - 0.43 0.44 0.43 29 28136 40 8 30 2 37

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 33
Total TN 60481
Total FP 78
Total FP CONTRA 3
Total FP INCONS 71
Total FP COMP 4
Total FN 104
Total Scores
MCC 0.271
Average MCC ± 95% Confidence Intervals 0.275 ± 1.303
Sensitivity 0.241
Positive Predictive Value 0.308
Nr of predictions 2

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.17 0.15 0.20 11 32329 45 3 42 0 60
ASE_00429 - 0.38 0.33 0.43 22 28152 33 0 29 4 44

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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