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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & Murlet(20) [.zip] - may take several seconds...


Overview

Metric Afold Murlet(20)
MCC 0.540 > 0.523
Average MCC ± 95% Confidence Intervals 0.536 ± 0.029 > 0.526 ± 0.027
Sensitivity 0.527 > 0.382
Positive Predictive Value 0.556 < 0.717
Total TP 5389 > 3910
Total TN 5842787 < 5847033
Total FP 4854 > 1656
Total FP CONTRA 500 > 155
Total FP INCONS 3809 > 1387
Total FP COMP 545 > 114
Total FN 4841 < 6320
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Afold and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and Murlet(20)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 5389
Total TN 5842787
Total FP 4854
Total FP CONTRA 500
Total FP INCONS 3809
Total FP COMP 545
Total FN 4841
Total Scores
MCC 0.540
Average MCC ± 95% Confidence Intervals 0.536 ± 0.029
Sensitivity 0.527
Positive Predictive Value 0.556
Nr of predictions 97

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.51 0.52 0.51 50 47797 49 10 38 1 47
ASE_00007 0.56 0.53 0.59 58 59586 45 1 40 4 52
ASE_00028 0.58 0.56 0.61 70 84551 54 4 41 9 56
ASE_00040 0.50 0.47 0.53 63 78883 63 5 52 6 70
ASE_00064 0.43 0.43 0.44 38 45364 54 5 44 5 51
ASE_00068 0.33 0.32 0.36 27 37599 50 2 47 1 58
ASE_00075 0.65 0.59 0.72 95 108679 46 3 34 9 67
ASE_00077 0.52 0.51 0.54 44 45068 39 6 32 1 42
ASE_00078 0.67 0.67 0.67 56 42988 32 5 22 5 27
ASE_00080 0.50 0.48 0.52 59 71518 59 3 51 5 64
ASE_00081 0.46 0.45 0.46 44 49675 53 5 46 2 53
ASE_00082 0.57 0.54 0.61 63 70396 51 1 40 10 53
ASE_00083 0.71 0.67 0.76 74 62383 32 1 23 8 36
ASE_00084 0.72 0.71 0.73 70 53532 30 6 20 4 29
ASE_00087 0.56 0.51 0.61 74 88288 54 5 43 6 70
ASE_00092 0.68 0.65 0.72 73 63444 35 3 26 6 40
ASE_00104 0.53 0.50 0.56 60 64153 49 8 40 1 59
ASE_00115 0.55 0.54 0.56 55 54517 51 1 42 8 46
ASE_00119 0.63 0.60 0.67 65 62738 35 1 31 3 43
ASE_00123 0.44 0.42 0.46 36 38425 48 3 39 6 49
ASE_00135 0.45 0.44 0.45 48 63084 63 8 50 5 61
ASE_00138 0.51 0.49 0.53 40 40395 36 4 31 1 41
ASE_00146 0.55 0.52 0.59 64 70768 50 2 42 6 60
ASE_00153 0.66 0.67 0.65 49 57555 68 2 24 42 24
ASE_00163 0.64 0.63 0.66 59 53211 43 4 27 12 34
ASE_00170 0.70 0.68 0.72 63 48740 27 2 23 2 30
ASE_00174 0.59 0.57 0.62 62 60975 42 6 32 4 47
ASE_00179 0.64 0.65 0.62 55 44164 35 7 27 1 29
ASE_00180 0.71 0.69 0.74 69 51267 31 2 22 7 31
ASE_00182 0.60 0.58 0.62 79 84128 49 6 42 1 57
ASE_00185 0.72 0.70 0.74 89 73416 38 6 25 7 39
ASE_00186 0.73 0.69 0.78 91 78887 30 3 22 5 41
ASE_00190 0.49 0.46 0.52 41 45372 44 7 31 6 49
ASE_00212 0.70 0.67 0.74 99 93827 39 3 32 4 49
ASE_00214 0.72 0.72 0.73 74 56178 36 4 24 8 29
ASE_00215 0.54 0.51 0.57 50 48429 39 4 33 2 49
ASE_00217 0.40 0.37 0.45 33 40396 48 3 38 7 57
ASE_00221 0.49 0.45 0.54 53 64522 48 3 42 3 64
ASE_00228 0.52 0.53 0.50 46 46879 46 14 32 0 40
ASE_00229 0.61 0.61 0.62 53 42400 33 8 25 0 34
ASE_00238 0.59 0.59 0.60 67 64150 50 2 42 6 47
ASE_00241 0.49 0.49 0.49 43 43868 47 7 38 2 44
ASE_00255 0.64 0.62 0.66 80 74570 45 7 34 4 50
ASE_00257 0.55 0.55 0.55 53 50944 47 4 39 4 44
ASE_00267 0.32 0.31 0.34 27 45070 62 5 48 9 61
ASE_00270 0.76 0.73 0.80 94 72272 29 4 20 5 34
ASE_00279 0.68 0.66 0.71 67 53206 35 3 25 7 34
ASE_00280 0.36 0.36 0.37 35 51909 65 4 55 6 63
ASE_00283 0.75 0.73 0.77 78 61675 30 3 20 7 29
ASE_00285 0.75 0.70 0.80 86 68899 28 3 18 7 36
ASE_00292 0.62 0.58 0.66 80 81689 43 2 39 2 58
ASE_00294 0.74 0.68 0.80 117 114335 32 2 27 3 54
ASE_00297 0.50 0.50 0.51 49 52878 53 4 44 5 49
ASE_00298 0.28 0.27 0.29 31 67420 79 9 68 2 82
ASE_00328 0.40 0.41 0.40 46 72656 75 3 66 6 66
ASE_00332 0.56 0.54 0.59 75 81682 55 2 51 2 63
ASE_00340 0.76 0.73 0.78 62 45977 26 6 11 9 23
ASE_00361 0.51 0.49 0.53 62 75349 59 7 48 4 65
ASE_00362 0.61 0.60 0.61 55 48115 39 6 29 4 36
ASE_00363 0.53 0.54 0.53 51 51263 47 5 41 1 43
ASE_00364 0.42 0.42 0.43 44 54182 63 4 55 4 61
ASE_00366 0.54 0.56 0.53 55 58549 52 10 39 3 43
ASE_00367 0.28 0.29 0.27 25 42979 68 8 59 1 61
ASE_00372 0.63 0.62 0.65 62 51907 39 6 28 5 38
ASE_00376 0.48 0.46 0.50 48 56857 52 4 44 4 57
ASE_00382 0.49 0.49 0.50 41 41823 45 6 35 4 43
ASE_00384 0.41 0.39 0.43 36 48432 58 2 46 10 56
ASE_00386 0.65 0.65 0.65 62 50307 41 3 31 7 34
ASE_00387 0.43 0.43 0.43 45 55841 59 6 53 0 59
ASE_00388 0.43 0.42 0.44 37 45669 53 3 44 6 52
ASE_00390 0.44 0.42 0.47 36 42118 52 6 35 11 49
ASE_00393 0.37 0.35 0.39 33 47811 58 2 49 7 60
ASE_00394 0.69 0.68 0.70 63 46881 29 5 22 2 30
ASE_00395 0.65 0.63 0.68 53 41538 35 1 24 10 31
ASE_00396 0.16 0.16 0.16 13 41535 71 2 66 3 70
ASE_00397 0.54 0.54 0.54 57 54510 51 4 44 3 48
ASE_00398 0.61 0.58 0.65 60 55852 37 1 32 4 44
ASE_00400 0.53 0.53 0.54 56 57866 51 7 41 3 50
ASE_00402 0.41 0.40 0.43 34 42406 52 7 39 6 51
ASE_00404 0.55 0.54 0.57 46 42990 43 0 35 8 39
ASE_00411 0.35 0.35 0.35 31 49366 63 7 51 5 58
ASE_00416 0.65 0.61 0.68 78 77307 43 0 36 7 49
ASE_00419 0.75 0.73 0.78 75 54850 26 5 16 5 28
ASE_00422 0.44 0.44 0.45 41 46880 56 5 45 6 53
ASE_00428 0.51 0.50 0.53 62 76520 58 5 49 4 63
ASE_00430 0.64 0.63 0.66 61 46878 39 5 27 7 36
ASE_00437 0.42 0.39 0.46 53 79285 64 4 59 1 82
ASE_00448 0.22 0.22 0.23 25 64150 91 6 80 5 87
ASE_00451 0.61 0.57 0.66 71 70768 40 2 35 3 54
RFA_00599 0.67 0.70 0.64 78 101353 66 16 28 22 33
RFA_00601 0.09 0.11 0.08 12 99092 139 35 96 8 102
RFA_00602 0.50 0.53 0.47 62 101344 91 18 51 22 54
TMR_00038 0.25 0.25 0.25 28 71140 89 12 73 4 82
TMR_00046 0.47 0.48 0.46 46 62734 61 10 45 6 50
TMR_00048 0.35 0.37 0.34 35 64876 73 9 60 4 60
TMR_00458 0.22 0.22 0.23 20 63458 76 7 61 8 73
TMR_00568 0.57 0.57 0.58 56 60629 50 3 38 9 43

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 3910
Total TN 5847033
Total FP 1656
Total FP CONTRA 155
Total FP INCONS 1387
Total FP COMP 114
Total FN 6320
Total Scores
MCC 0.523
Average MCC ± 95% Confidence Intervals 0.526 ± 0.027
Sensitivity 0.382
Positive Predictive Value 0.717
Nr of predictions 97

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.46 0.34 0.61 33 47841 21 1 20 0 64
ASE_00007 0.71 0.57 0.89 63 59614 8 2 6 0 47
ASE_00028 0.56 0.40 0.77 51 84600 15 5 10 0 75
ASE_00040 0.62 0.43 0.90 57 78940 6 0 6 0 76
ASE_00064 0.55 0.39 0.76 35 45405 14 3 8 3 54
ASE_00068 0.62 0.42 0.90 36 37635 4 3 1 0 49
ASE_00075 0.51 0.34 0.76 55 108739 19 1 16 2 107
ASE_00077 0.48 0.35 0.67 30 45105 18 0 15 3 56
ASE_00078 0.64 0.53 0.79 44 43015 12 3 9 0 39
ASE_00080 0.31 0.21 0.46 26 71574 31 3 28 0 97
ASE_00081 0.73 0.58 0.93 56 49710 5 0 4 1 41
ASE_00082 0.27 0.20 0.37 23 70438 42 2 37 3 93
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00084 0.53 0.36 0.77 36 53581 12 0 11 1 63
ASE_00087 0.35 0.21 0.58 30 88358 22 0 22 0 114
ASE_00092 0.58 0.40 0.85 45 63493 10 0 8 2 68
ASE_00104 0.51 0.38 0.69 45 64196 20 1 19 0 74
ASE_00115 0.46 0.30 0.71 30 54573 12 1 11 0 71
ASE_00119 0.11 0.08 0.16 9 62779 48 2 45 1 99
ASE_00123 0.55 0.40 0.76 34 38458 11 0 11 0 51
ASE_00135 0.34 0.24 0.49 26 63137 29 3 24 2 83
ASE_00138 0.60 0.47 0.76 38 40420 13 0 12 1 43
ASE_00146 0.70 0.56 0.87 69 70797 13 0 10 3 55
ASE_00153 0.34 0.23 0.50 17 57596 26 3 14 9 56
ASE_00163 0.47 0.32 0.70 30 53258 13 0 13 0 63
ASE_00170 0.52 0.37 0.74 34 48782 12 0 12 0 59
ASE_00174 0.30 0.23 0.39 25 61011 43 2 37 4 84
ASE_00179 0.49 0.40 0.61 34 44197 22 0 22 0 50
ASE_00180 0.70 0.55 0.90 55 51299 6 2 4 0 45
ASE_00182 0.24 0.15 0.41 20 84206 31 1 28 2 116
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00186 0.61 0.45 0.84 59 78933 11 1 10 0 73
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00212 0.55 0.39 0.78 58 93887 16 1 15 0 90
ASE_00214 0.40 0.27 0.58 28 56232 21 1 19 1 75
ASE_00215 0.46 0.31 0.69 31 48471 14 4 10 0 68
ASE_00217 0.66 0.50 0.87 45 40418 7 1 6 0 45
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00241 0.66 0.55 0.79 48 43895 16 2 11 3 39
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00280 0.67 0.54 0.84 53 51940 10 3 7 0 45
ASE_00283 0.55 0.41 0.73 44 61716 16 0 16 0 63
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00292 0.52 0.36 0.74 50 81742 18 1 17 0 88
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00297 0.59 0.41 0.85 40 52928 10 0 7 3 58
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00328 0.59 0.48 0.72 54 72696 27 5 16 6 58
ASE_00332 0.63 0.47 0.83 65 81732 13 2 11 0 73
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00361 0.57 0.39 0.82 50 75405 11 1 10 0 77
ASE_00362 0.56 0.38 0.81 35 48162 12 0 8 4 56
ASE_00363 0.61 0.44 0.85 41 51312 7 0 7 0 53
ASE_00364 0.58 0.38 0.89 40 54240 5 0 5 0 65
ASE_00366 0.49 0.36 0.67 35 58601 19 0 17 2 63
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00382 0.65 0.51 0.83 43 41853 9 2 7 0 41
ASE_00384 0.59 0.43 0.80 40 48466 10 2 8 0 52
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00387 0.64 0.45 0.90 47 55893 5 0 5 0 57
ASE_00388 0.53 0.38 0.72 34 45706 16 1 12 3 55
ASE_00390 0.77 0.64 0.93 54 42137 6 1 3 2 31
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00394 0.56 0.41 0.78 38 46922 11 1 10 0 55
ASE_00395 0.68 0.51 0.90 43 41568 5 0 5 0 41
ASE_00396 0.62 0.47 0.81 39 41568 9 0 9 0 44
ASE_00397 0.63 0.45 0.89 47 54562 9 1 5 3 58
ASE_00398 0.49 0.32 0.75 33 55901 12 0 11 1 71
ASE_00400 0.47 0.36 0.61 38 57908 25 3 21 1 68
ASE_00402 0.55 0.35 0.86 30 42451 5 2 3 0 55
ASE_00404 0.72 0.55 0.94 47 43021 4 0 3 1 38
ASE_00411 0.59 0.39 0.88 35 49415 5 0 5 0 54
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00419 0.49 0.33 0.74 34 54900 12 2 10 0 69
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00448 0.63 0.49 0.82 55 64194 12 3 9 0 57
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
RFA_00599 0.44 0.34 0.58 38 101409 33 1 27 5 73
RFA_00601 0.31 0.23 0.42 26 99173 43 3 33 7 88
RFA_00602 0.24 0.16 0.35 19 101421 41 2 33 6 97
TMR_00038 0.67 0.53 0.84 58 71184 13 5 6 2 52
TMR_00046 0.60 0.52 0.69 50 62763 23 6 16 1 46
TMR_00048 0.56 0.48 0.66 46 64910 29 9 15 5 49
TMR_00458 0.50 0.41 0.61 38 63484 29 4 20 5 55
TMR_00568 0.72 0.64 0.82 63 60649 18 3 11 4 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.