CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CMfinder(seed)		RNAwolf
MCC	0.350	>	0.237
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060	>	0.247 ± 0.105
Sensitivity	0.159	<	0.248
Positive Predictive Value	0.770	>	0.229
Total TP	234	<	364
Total TN	1036346	>	1035058
Total FP	77	<	1462
Total FP CONTRA	3	<	219
Total FP INCONS	67	<	1009
Total FP COMP	7	<	234
Total FN	1236	>	1106
P-value	2.24270395587e-08

Comparison of performance of CMfinder(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Total Scores
MCC	0.237
Average MCC ± 95% Confidence Intervals	0.247 ± 0.105
Sensitivity	0.248
Positive Predictive Value	0.229
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.03	0.03	0.03	4	103598	147	24	114	9	111
CRW_00016	Intron_gpI links to Rfam database...	0.24	0.23	0.24	28	77305	101	10	78	13	92
CRW_00610	Intron_gpI links to Rfam database...	0.52	0.52	0.52	42	36234	53	4	35	14	39
CRW_00613	Intron_gpI links to Rfam database...	0.60	0.62	0.59	48	34898	50	1	33	16	30
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.12	0.07	7	121673	167	34	57	76	50
CRW_00618	Intron_gpI links to Rfam database...	0.01	0.02	0.01	1	56208	107	13	58	36	60
CRW_00633	Intron_gpI links to Rfam database...	0.29	0.29	0.30	31	63442	76	12	61	3	75
CRW_00634	Intron_gpI links to Rfam database...	0.19	0.22	0.17	21	64493	110	25	81	4	73
CRW_00670	Intron_gpI links to Rfam database...	0.35	0.35	0.35	42	70006	81	12	65	4	78
CRW_00671	Intron_gpI links to Rfam database...	0.13	0.13	0.13	15	62723	100	11	86	3	102
CRW_00672	Intron_gpI links to Rfam database...	0.06	0.06	0.06	7	72276	114	17	90	7	104
CRW_00674	Intron_gpI links to Rfam database...	0.28	0.28	0.28	35	83310	106	12	79	15	89
CRW_00676	Intron_gpI links to Rfam database...	0.16	0.17	0.16	19	93407	113	22	80	11	96
CRW_00692	Intron_gpI links to Rfam database...	0.18	0.19	0.18	17	68539	100	16	63	21	73
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.58	0.57	47	26946	37	6	29	2	34

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.