CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CentroidAlifold(seed)		CMfinder(seed)
MCC	0.420	>	0.350
Average MCC ± 95% Confidence Intervals	0.423 ± 0.047	>	0.358 ± 0.060
Sensitivity	0.246	>	0.159
Positive Predictive Value	0.717	<	0.770
Total TP	362	>	234
Total TN	1036145	<	1036346
Total FP	210	>	77
Total FP CONTRA	18	>	3
Total FP INCONS	125	>	67
Total FP COMP	67	>	7
Total FN	1108	<	1236
P-value	2.22210847902e-08

Comparison of performance of CentroidAlifold(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and CMfinder(seed)).

Total Scores
MCC	0.420
Average MCC ± 95% Confidence Intervals	0.423 ± 0.047
Sensitivity	0.246
Positive Predictive Value	0.717
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.21	0.65	24	103703	17	1	12	4	91
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.20	0.65	24	77384	16	1	12	3	96
CRW_00610	Intron_gpI links to Rfam database...	0.51	0.33	0.77	27	36280	11	1	7	3	54
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.32	0.71	25	34945	14	0	10	4	53
CRW_00614	Intron_gpI links to Rfam database...	0.43	0.30	0.63	17	121744	16	2	8	6	40
CRW_00618	Intron_gpI links to Rfam database...	0.41	0.28	0.61	17	56252	12	3	8	1	44
CRW_00633	Intron_gpI links to Rfam database...	0.31	0.17	0.58	18	63515	14	2	11	1	88
CRW_00634	Intron_gpI links to Rfam database...	0.35	0.20	0.61	19	64589	20	1	11	8	75
CRW_00670	Intron_gpI links to Rfam database...	0.49	0.28	0.89	33	70088	8	0	4	4	87
CRW_00671	Intron_gpI links to Rfam database...	0.50	0.28	0.89	33	62798	8	0	4	4	84
CRW_00672	Intron_gpI links to Rfam database...	0.51	0.30	0.89	33	72353	8	0	4	4	78
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.16	0.54	20	83399	20	6	11	3	104
CRW_00676	Intron_gpI links to Rfam database...	0.35	0.17	0.69	20	93499	20	0	9	11	95
CRW_00692	Intron_gpI links to Rfam database...	0.39	0.22	0.69	20	68606	20	0	9	11	70
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.40	0.84	32	26990	6	1	5	0	49

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.