CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(seed)		Carnac(seed)
MCC	0.650	>	0.000
Average MCC ± 95% Confidence Intervals	0.638 ± 0.053	>	0.000 ± 0.000
Sensitivity	0.475	>	0.000
Positive Predictive Value	0.891	>	0.000
Total TP	2173	>	0
Total TN	3423437	<	3425877
Total FP	397	>	0
Total FP CONTRA	23	>	0
Total FP INCONS	244	>	0
Total FP COMP	130	>	0
Total FN	2398	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and Carnac(seed)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	2173
Total TN	3423437
Total FP	397
Total FP CONTRA	23
Total FP INCONS	244
Total FP COMP	130
Total FN	2398

Total Scores
MCC	0.650
Average MCC ± 95% Confidence Intervals	0.638 ± 0.053
Sensitivity	0.475
Positive Predictive Value	0.891
Nr of predictions	48

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.81	0.65	1.00	49	34142	0	0	0	0	26
ASE_00002	RNaseP_arch links to Rfam database...	0.82	0.67	1.00	49	35462	0	0	0	0	24
ASE_00009	RNaseP_arch links to Rfam database...	0.79	0.67	0.94	45	26058	3	0	3	0	22
ASE_00014	RNaseP_arch links to Rfam database...	0.74	0.58	0.95	61	54221	3	0	3	0	45
ASE_00116	RNaseP_arch links to Rfam database...	0.86	0.76	0.98	50	31575	1	0	1	0	16
ASE_00120	RNaseP_arch links to Rfam database...	0.79	0.64	0.98	60	46910	2	0	1	1	34
ASE_00121	RNaseP_arch links to Rfam database...	0.81	0.66	0.98	61	45088	1	0	1	0	31
ASE_00145	RNaseP_arch links to Rfam database...	0.77	0.59	1.00	66	70059	0	0	0	0	45
ASE_00148	RNaseP_arch links to Rfam database...	0.62	0.41	0.95	63	112509	3	0	3	0	91
ASE_00154	RNaseP_arch links to Rfam database...	0.75	0.59	0.95	63	65275	3	0	3	0	44
ASE_00155	RNaseP_arch links to Rfam database...	0.68	0.46	1.00	66	93462	0	0	0	0	76
ASE_00187	RNaseP_arch links to Rfam database...	0.69	0.51	0.92	59	68571	5	1	4	0	56
ASE_00196	RNaseP_arch links to Rfam database...	0.82	0.69	0.96	52	31572	2	0	2	0	23
ASE_00205	RNaseP_arch links to Rfam database...	0.82	0.67	1.00	60	45996	1	0	0	1	30
ASE_00209	RNaseP_arch links to Rfam database...	0.83	0.69	0.98	61	43009	1	0	1	0	27
ASE_00210	RNaseP_arch links to Rfam database...	0.74	0.65	0.86	42	27212	9	0	7	2	23
ASE_00213	RNaseP_arch links to Rfam database...	0.83	0.71	0.98	47	27213	3	0	1	2	19
ASE_00222	RNaseP_arch links to Rfam database...	0.65	0.42	1.00	66	112035	0	0	0	0	91
ASE_00346	RNaseP_arch links to Rfam database...	0.61	0.49	0.75	48	48141	16	0	16	0	49
ASE_00359	RNaseP_arch links to Rfam database...	0.77	0.61	0.98	49	42728	2	0	1	1	31
ASE_00360	RNaseP_arch links to Rfam database...	0.87	0.77	0.98	50	29352	1	0	1	0	15
ASE_00417	RNaseP_arch links to Rfam database...	0.80	0.65	0.98	65	54549	1	0	1	0	35
ASE_00418	RNaseP_arch links to Rfam database...	0.81	0.67	0.98	50	38730	1	0	1	0	25
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.21	0.65	24	103703	17	1	12	4	91
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.20	0.65	24	77384	16	1	12	3	96
CRW_00610	Intron_gpI links to Rfam database...	0.51	0.33	0.77	27	36280	11	1	7	3	54
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.32	0.71	25	34945	14	0	10	4	53
CRW_00614	Intron_gpI links to Rfam database...	0.43	0.30	0.63	17	121744	16	2	8	6	40
CRW_00618	Intron_gpI links to Rfam database...	0.41	0.28	0.61	17	56252	12	3	8	1	44
CRW_00619	Intron_gpI links to Rfam database...	0.53	0.30	0.92	22	165001	5	0	2	3	51
CRW_00620	Intron_gpI links to Rfam database...	0.44	0.29	0.69	18	150949	18	0	8	10	45
CRW_00621	Intron_gpI links to Rfam database...	0.40	0.27	0.61	19	153150	14	3	9	2	52
CRW_00623	Intron_gpI links to Rfam database...	0.49	0.29	0.83	24	129766	9	1	4	4	59
CRW_00633	Intron_gpI links to Rfam database...	0.31	0.17	0.58	18	63515	14	2	11	1	88
CRW_00634	Intron_gpI links to Rfam database...	0.35	0.20	0.61	19	64589	20	1	11	8	75
CRW_00670	Intron_gpI links to Rfam database...	0.49	0.28	0.89	33	70088	8	0	4	4	87
CRW_00671	Intron_gpI links to Rfam database...	0.50	0.28	0.89	33	62798	8	0	4	4	84
CRW_00672	Intron_gpI links to Rfam database...	0.51	0.30	0.89	33	72353	8	0	4	4	78
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.16	0.54	20	83399	20	6	11	3	104
CRW_00676	Intron_gpI links to Rfam database...	0.35	0.17	0.69	20	93499	20	0	9	11	95
CRW_00692	Intron_gpI links to Rfam database...	0.39	0.22	0.69	20	68606	20	0	9	11	70
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.40	0.84	32	26990	6	1	5	0	49
RFA_00597	Telomerase-vert links to Rfam database...	0.73	0.64	0.83	70	97819	19	0	14	5	39
RFA_00598	Telomerase-vert links to Rfam database...	0.72	0.63	0.81	64	84587	26	0	15	11	37
RFA_00599	Telomerase-vert links to Rfam database...	0.85	0.73	0.99	81	101393	4	0	1	3	30
RFA_00600	Telomerase-vert links to Rfam database...	0.79	0.68	0.92	68	120221	15	0	6	9	32
RFA_00601	Telomerase-vert links to Rfam database...	0.82	0.71	0.95	81	99150	9	0	4	5	33
RFA_00602	Telomerase-vert links to Rfam database...	0.81	0.71	0.93	82	101387	10	0	6	4	34

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]