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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) Murlet(20)
MCC 0.726 > 0.533
Average MCC ± 95% Confidence Intervals 0.727 ± 0.016 > 0.534 ± 0.025
Sensitivity 0.554 > 0.389
Positive Predictive Value 0.951 > 0.732
Total TP 6274 > 4397
Total TN 6436368 < 6436955
Total FP 406 < 1732
Total FP CONTRA 37 < 147
Total FP INCONS 284 < 1464
Total FP COMP 85 < 121
Total FN 5041 < 6918
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and Murlet(20)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 6274
Total TN 6436368
Total FP 406
Total FP CONTRA 37
Total FP INCONS 284
Total FP COMP 85
Total FN 5041
Total Scores
MCC 0.726
Average MCC ± 95% Confidence Intervals 0.727 ± 0.016
Sensitivity 0.554
Positive Predictive Value 0.951
Nr of predictions 106

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.61 0.45 0.83 44 47842 9 0 9 0 53
ASE_00007 0.83 0.71 0.98 78 59605 2 0 2 0 32
ASE_00018 0.78 0.60 1.00 81 80520 0 0 0 0 53
ASE_00022 0.80 0.65 1.00 80 82948 5 0 0 5 44
ASE_00028 0.80 0.64 1.00 81 84585 3 0 0 3 45
ASE_00035 0.77 0.64 0.94 75 70420 8 0 5 3 43
ASE_00040 0.77 0.59 1.00 79 78924 2 0 0 2 54
ASE_00064 0.77 0.60 1.00 53 45398 0 0 0 0 36
ASE_00068 0.54 0.38 0.78 32 37634 9 0 9 0 53
ASE_00075 0.64 0.44 0.92 71 108734 11 1 5 5 91
ASE_00077 0.79 0.64 0.96 55 45093 2 1 1 0 31
ASE_00078 0.83 0.69 1.00 57 43014 0 0 0 0 26
ASE_00080 0.45 0.30 0.66 37 71575 19 1 18 0 86
ASE_00081 0.77 0.59 1.00 57 49713 0 0 0 0 40
ASE_00082 0.66 0.43 1.00 50 70450 6 0 0 6 66
ASE_00083 0.72 0.52 1.00 57 62424 0 0 0 0 53
ASE_00084 0.75 0.57 0.98 56 53571 1 1 0 0 43
ASE_00087 0.60 0.38 0.95 54 88353 3 0 3 0 90
ASE_00092 0.70 0.50 0.98 56 63489 1 1 0 0 57
ASE_00104 0.81 0.67 0.99 80 64180 1 0 1 0 39
ASE_00107 0.78 0.63 0.96 80 73070 3 0 3 0 47
ASE_00115 0.74 0.54 1.00 55 54560 0 0 0 0 46
ASE_00119 0.66 0.44 0.98 48 62786 1 1 0 0 60
ASE_00123 0.68 0.48 0.95 41 38460 2 0 2 0 44
ASE_00135 0.53 0.39 0.74 42 63133 15 0 15 0 67
ASE_00138 0.79 0.63 1.00 51 40419 0 0 0 0 30
ASE_00142 0.77 0.61 0.97 75 67084 4 0 2 2 47
ASE_00146 0.78 0.62 0.97 77 70797 2 0 2 0 47
ASE_00153 0.67 0.53 0.85 39 57584 7 1 6 0 34
ASE_00163 0.77 0.59 1.00 55 53246 0 0 0 0 38
ASE_00170 0.78 0.60 1.00 56 48772 0 0 0 0 37
ASE_00174 0.60 0.43 0.82 47 61018 10 1 9 0 62
ASE_00179 0.79 0.63 0.98 53 44199 2 0 1 1 31
ASE_00180 0.73 0.54 0.98 54 51305 1 1 0 0 46
ASE_00182 0.61 0.40 0.95 54 84198 3 0 3 0 82
ASE_00184 0.75 0.56 1.00 57 54558 0 0 0 0 45
ASE_00185 0.64 0.41 0.98 53 73482 1 1 0 0 75
ASE_00186 0.66 0.51 0.86 67 78925 14 0 11 3 65
ASE_00190 0.74 0.54 1.00 49 45402 3 0 0 3 41
ASE_00212 0.63 0.45 0.89 66 93887 9 0 8 1 82
ASE_00214 0.73 0.54 0.98 56 56223 2 1 0 1 47
ASE_00215 0.51 0.32 0.82 32 48477 7 0 7 0 67
ASE_00217 0.82 0.67 1.00 60 40410 1 0 0 1 30
ASE_00221 0.83 0.70 0.99 82 64537 1 0 1 0 35
ASE_00228 0.72 0.57 0.91 49 46917 6 3 2 1 37
ASE_00229 0.78 0.61 1.00 53 42433 2 0 0 2 34
ASE_00238 0.61 0.44 0.86 50 64203 8 2 6 0 64
ASE_00241 0.79 0.64 0.98 56 43899 1 0 1 0 31
ASE_00248 0.84 0.71 1.00 81 62400 1 0 0 1 33
ASE_00255 0.64 0.51 0.80 66 74609 16 0 16 0 64
ASE_00257 0.68 0.52 0.91 50 50985 5 1 4 0 47
ASE_00267 0.80 0.64 1.00 56 45094 0 0 0 0 32
ASE_00270 0.55 0.34 0.90 43 72342 6 0 5 1 85
ASE_00279 0.73 0.54 0.98 55 53245 1 0 1 0 46
ASE_00280 0.74 0.57 0.97 56 51945 2 1 1 0 42
ASE_00281 0.78 0.63 0.98 55 44495 1 0 1 0 33
ASE_00283 0.72 0.52 0.98 56 61719 1 0 1 0 51
ASE_00285 0.68 0.47 1.00 57 68949 0 0 0 0 65
ASE_00292 0.76 0.58 1.00 80 81730 1 0 0 1 58
ASE_00294 0.68 0.47 0.98 81 114398 2 0 2 0 90
ASE_00297 0.61 0.45 0.83 44 52922 9 2 7 0 54
ASE_00298 0.70 0.50 0.98 56 67471 1 1 0 0 57
ASE_00318 0.79 0.62 1.00 73 80127 6 0 0 6 45
ASE_00328 0.83 0.70 1.00 78 72693 5 0 0 5 34
ASE_00332 0.78 0.60 1.00 83 81727 0 0 0 0 55
ASE_00335 0.81 0.66 1.00 77 75389 7 0 0 7 39
ASE_00340 0.73 0.56 0.94 48 46005 7 0 3 4 37
ASE_00353 0.72 0.52 0.98 56 57913 2 1 0 1 51
ASE_00361 0.65 0.43 0.98 55 75410 1 1 0 0 72
ASE_00362 0.78 0.62 1.00 56 48149 1 0 0 1 35
ASE_00363 0.70 0.54 0.89 51 51303 6 0 6 0 43
ASE_00364 0.66 0.49 0.89 51 54228 6 1 5 0 54
ASE_00366 0.69 0.53 0.90 52 58595 6 2 4 0 46
ASE_00367 0.81 0.65 1.00 56 43015 1 0 0 1 30
ASE_00372 0.73 0.54 0.98 54 51948 1 0 1 0 46
ASE_00376 0.68 0.50 0.93 53 56896 4 0 4 0 52
ASE_00382 0.80 0.64 1.00 54 41851 1 0 0 1 30
ASE_00384 0.78 0.61 1.00 56 48460 0 0 0 0 36
ASE_00386 0.77 0.59 1.00 57 50346 0 0 0 0 39
ASE_00387 0.63 0.46 0.87 48 55890 7 0 7 0 56
ASE_00388 0.77 0.60 1.00 53 45700 1 0 0 1 36
ASE_00390 0.78 0.62 0.98 53 42141 1 0 1 0 32
ASE_00393 0.71 0.56 0.91 52 47838 5 0 5 0 41
ASE_00394 0.76 0.58 1.00 54 46917 0 0 0 0 39
ASE_00395 0.80 0.64 1.00 54 41562 0 0 0 0 30
ASE_00396 0.81 0.65 1.00 54 41562 0 0 0 0 29
ASE_00397 0.74 0.54 1.00 57 54558 0 0 0 0 48
ASE_00398 0.72 0.52 1.00 54 55891 0 0 0 0 50
ASE_00400 0.72 0.52 1.00 55 57915 1 0 0 1 51
ASE_00402 0.80 0.65 1.00 55 42431 0 0 0 0 30
ASE_00404 0.80 0.65 1.00 55 43016 1 0 0 1 30
ASE_00406 0.78 0.61 1.00 57 48771 0 0 0 0 37
ASE_00411 0.67 0.55 0.82 49 49395 11 5 6 0 40
ASE_00412 0.63 0.47 0.84 49 58253 9 2 7 0 56
ASE_00416 0.76 0.61 0.94 78 77338 5 1 4 0 49
ASE_00419 0.67 0.50 0.89 51 54889 6 2 4 0 52
ASE_00422 0.74 0.57 0.96 54 46915 3 0 2 1 40
ASE_00423 0.77 0.64 0.93 70 56878 6 0 5 1 39
ASE_00428 0.77 0.62 0.94 78 76553 5 1 4 0 47
ASE_00430 0.73 0.55 0.98 53 46917 1 0 1 0 44
ASE_00437 0.52 0.40 0.67 54 79320 27 0 27 0 81
ASE_00448 0.81 0.69 0.95 77 64180 4 0 4 0 35
ASE_00451 0.79 0.64 0.96 80 70793 3 0 3 0 45
RFA_00599 0.85 0.73 0.99 81 101393 4 0 1 3 30
RFA_00601 0.82 0.71 0.95 81 99150 9 0 4 5 33
RFA_00602 0.81 0.71 0.93 82 101387 10 0 6 4 34

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 4397
Total TN 6436955
Total FP 1732
Total FP CONTRA 147
Total FP INCONS 1464
Total FP COMP 121
Total FN 6918
Total Scores
MCC 0.533
Average MCC ± 95% Confidence Intervals 0.534 ± 0.025
Sensitivity 0.389
Positive Predictive Value 0.732
Nr of predictions 106

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.46 0.34 0.61 33 47841 21 1 20 0 64
ASE_00007 0.71 0.57 0.89 63 59614 8 2 6 0 47
ASE_00018 0.61 0.45 0.82 60 80528 13 3 10 0 74
ASE_00022 0.67 0.50 0.89 62 82958 15 0 8 7 62
ASE_00028 0.56 0.40 0.77 51 84600 15 5 10 0 75
ASE_00035 0.62 0.49 0.79 58 70427 17 4 11 2 60
ASE_00040 0.62 0.43 0.90 57 78940 6 0 6 0 76
ASE_00064 0.55 0.39 0.76 35 45405 14 3 8 3 54
ASE_00068 0.62 0.42 0.90 36 37635 4 3 1 0 49
ASE_00075 0.51 0.34 0.76 55 108739 19 1 16 2 107
ASE_00077 0.48 0.35 0.67 30 45105 18 0 15 3 56
ASE_00078 0.64 0.53 0.79 44 43015 12 3 9 0 39
ASE_00080 0.31 0.21 0.46 26 71574 31 3 28 0 97
ASE_00081 0.73 0.58 0.93 56 49710 5 0 4 1 41
ASE_00082 0.27 0.20 0.37 23 70438 42 2 37 3 93
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00084 0.53 0.36 0.77 36 53581 12 0 11 1 63
ASE_00087 0.35 0.21 0.58 30 88358 22 0 22 0 114
ASE_00092 0.58 0.40 0.85 45 63493 10 0 8 2 68
ASE_00104 0.51 0.38 0.69 45 64196 20 1 19 0 74
ASE_00107 0.64 0.48 0.86 61 73082 13 2 8 3 66
ASE_00115 0.46 0.30 0.71 30 54573 12 1 11 0 71
ASE_00119 0.11 0.08 0.16 9 62779 48 2 45 1 99
ASE_00123 0.55 0.40 0.76 34 38458 11 0 11 0 51
ASE_00135 0.34 0.24 0.49 26 63137 29 3 24 2 83
ASE_00138 0.60 0.47 0.76 38 40420 13 0 12 1 43
ASE_00142 0.52 0.40 0.68 49 67089 23 1 22 0 73
ASE_00146 0.70 0.56 0.87 69 70797 13 0 10 3 55
ASE_00153 0.34 0.23 0.50 17 57596 26 3 14 9 56
ASE_00163 0.47 0.32 0.70 30 53258 13 0 13 0 63
ASE_00170 0.52 0.37 0.74 34 48782 12 0 12 0 59
ASE_00174 0.30 0.23 0.39 25 61011 43 2 37 4 84
ASE_00179 0.49 0.40 0.61 34 44197 22 0 22 0 50
ASE_00180 0.70 0.55 0.90 55 51299 6 2 4 0 45
ASE_00182 0.24 0.15 0.41 20 84206 31 1 28 2 116
ASE_00184 0.58 0.42 0.80 43 54561 11 2 9 0 59
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00186 0.61 0.45 0.84 59 78933 11 1 10 0 73
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00212 0.55 0.39 0.78 58 93887 16 1 15 0 90
ASE_00214 0.40 0.27 0.58 28 56232 21 1 19 1 75
ASE_00215 0.46 0.31 0.69 31 48471 14 4 10 0 68
ASE_00217 0.66 0.50 0.87 45 40418 7 1 6 0 45
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00241 0.66 0.55 0.79 48 43895 16 2 11 3 39
ASE_00248 0.76 0.63 0.91 72 62402 7 0 7 0 42
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00280 0.67 0.54 0.84 53 51940 10 3 7 0 45
ASE_00281 0.74 0.60 0.91 53 44493 5 0 5 0 35
ASE_00283 0.55 0.41 0.73 44 61716 16 0 16 0 63
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00292 0.52 0.36 0.74 50 81742 18 1 17 0 88
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00297 0.59 0.41 0.85 40 52928 10 0 7 3 58
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00318 0.66 0.49 0.89 58 80135 16 2 5 9 60
ASE_00328 0.59 0.48 0.72 54 72696 27 5 16 6 58
ASE_00332 0.63 0.47 0.83 65 81732 13 2 11 0 73
ASE_00335 0.60 0.48 0.76 56 75392 19 5 13 1 60
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00353 0.50 0.35 0.71 37 57918 15 0 15 0 70
ASE_00361 0.57 0.39 0.82 50 75405 11 1 10 0 77
ASE_00362 0.56 0.38 0.81 35 48162 12 0 8 4 56
ASE_00363 0.61 0.44 0.85 41 51312 7 0 7 0 53
ASE_00364 0.58 0.38 0.89 40 54240 5 0 5 0 65
ASE_00366 0.49 0.36 0.67 35 58601 19 0 17 2 63
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00382 0.65 0.51 0.83 43 41853 9 2 7 0 41
ASE_00384 0.59 0.43 0.80 40 48466 10 2 8 0 52
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00387 0.64 0.45 0.90 47 55893 5 0 5 0 57
ASE_00388 0.53 0.38 0.72 34 45706 16 1 12 3 55
ASE_00390 0.77 0.64 0.93 54 42137 6 1 3 2 31
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00394 0.56 0.41 0.78 38 46922 11 1 10 0 55
ASE_00395 0.68 0.51 0.90 43 41568 5 0 5 0 41
ASE_00396 0.62 0.47 0.81 39 41568 9 0 9 0 44
ASE_00397 0.63 0.45 0.89 47 54562 9 1 5 3 58
ASE_00398 0.49 0.32 0.75 33 55901 12 0 11 1 71
ASE_00400 0.47 0.36 0.61 38 57908 25 3 21 1 68
ASE_00402 0.55 0.35 0.86 30 42451 5 2 3 0 55
ASE_00404 0.72 0.55 0.94 47 43021 4 0 3 1 38
ASE_00406 0.60 0.44 0.84 41 48779 8 0 8 0 53
ASE_00411 0.59 0.39 0.88 35 49415 5 0 5 0 54
ASE_00412 0.51 0.32 0.79 34 58268 11 0 9 2 71
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00419 0.49 0.33 0.74 34 54900 12 2 10 0 69
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00423 0.65 0.53 0.79 58 56880 15 0 15 0 51
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00448 0.63 0.49 0.82 55 64194 12 3 9 0 57
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
RFA_00599 0.44 0.34 0.58 38 101409 33 1 27 5 73
RFA_00601 0.31 0.23 0.42 26 99173 43 3 33 7 88
RFA_00602 0.24 0.16 0.35 19 101421 41 2 33 6 97

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.