CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CentroidAlifold(seed)		RNASampler(20)
MCC	0.675	>	0.480
Average MCC ± 95% Confidence Intervals	0.672 ± 0.094	>	0.474 ± 0.098
Sensitivity	0.493	>	0.343
Positive Predictive Value	0.927	>	0.673
Total TP	405	>	282
Total TN	482459	<	482477
Total FP	38	<	163
Total FP CONTRA	2	<	16
Total FP INCONS	30	<	121
Total FP COMP	6	<	26
Total FN	417	<	540
P-value	0.0

Comparison of performance of CentroidAlifold(seed) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNASampler(20)).

Total Scores
MCC	0.675
Average MCC ± 95% Confidence Intervals	0.672 ± 0.094
Sensitivity	0.493
Positive Predictive Value	0.927
Nr of predictions	8

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.77	0.60	1.00	53	45398	0	0	0	0	36
ASE_00090	RNaseP_bact_a links to Rfam database...	0.75	0.56	1.00	57	55554	0	0	0	0	44
ASE_00135	RNaseP_bact_a links to Rfam database...	0.53	0.39	0.74	42	63133	15	0	15	0	67
ASE_00153	RNaseP_nuc links to Rfam database...	0.67	0.53	0.85	39	57584	7	1	6	0	34
ASE_00215	RNaseP_bact_a links to Rfam database...	0.51	0.32	0.82	32	48477	7	0	7	0	67
ASE_00328	RNaseP_bact_b links to Rfam database...	0.83	0.70	1.00	78	72693	5	0	0	5	34
ASE_00361	RNaseP_bact_a links to Rfam database...	0.65	0.43	0.98	55	75410	1	1	0	0	72
ASE_00441	RNaseP_bact_a links to Rfam database...	0.65	0.44	0.96	49	64210	3	0	2	1	63

Total Scores
MCC	0.480
Average MCC ± 95% Confidence Intervals	0.474 ± 0.098
Sensitivity	0.343
Positive Predictive Value	0.673
Nr of predictions	8

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.