CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CentroidFold		CMfinder(seed)
MCC	0.592	>	0.350
Average MCC ± 95% Confidence Intervals	0.574 ± 0.099	>	0.358 ± 0.060
Sensitivity	0.519	>	0.159
Positive Predictive Value	0.675	<	0.770
Total TP	763	>	234
Total TN	1035520	<	1036346
Total FP	505	>	77
Total FP CONTRA	82	>	3
Total FP INCONS	285	>	67
Total FP COMP	138	>	7
Total FN	707	<	1236
P-value	2.94377603181e-08

Comparison of performance of CentroidFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).

Total Scores
MCC	0.592
Average MCC ± 95% Confidence Intervals	0.574 ± 0.099
Sensitivity	0.519
Positive Predictive Value	0.675
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.45	0.32	0.63	37	103681	42	7	15	20	78
CRW_00016	Intron_gpI links to Rfam database...	0.74	0.66	0.84	79	77327	27	0	15	12	41
CRW_00610	Intron_gpI links to Rfam database...	0.57	0.52	0.63	42	36248	26	7	18	1	39
CRW_00613	Intron_gpI links to Rfam database...	0.78	0.72	0.85	56	34914	17	1	9	7	22
CRW_00614	Intron_gpI links to Rfam database...	0.23	0.23	0.24	13	121716	103	6	36	61	44
CRW_00618	Intron_gpI links to Rfam database...	0.23	0.21	0.24	13	56226	58	6	35	17	48
CRW_00633	Intron_gpI links to Rfam database...	0.65	0.56	0.77	59	63469	20	2	16	2	47
CRW_00634	Intron_gpI links to Rfam database...	0.53	0.47	0.59	44	64546	31	11	19	1	50
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.63	0.93	76	70043	6	0	6	0	44
CRW_00671	Intron_gpI links to Rfam database...	0.71	0.64	0.78	75	62739	23	1	20	2	42
CRW_00672	Intron_gpI links to Rfam database...	0.58	0.49	0.70	54	72313	26	7	16	3	57
CRW_00674	Intron_gpI links to Rfam database...	0.71	0.63	0.80	78	83339	24	5	14	5	46
CRW_00676	Intron_gpI links to Rfam database...	0.47	0.46	0.48	53	93418	61	14	43	4	62
CRW_00692	Intron_gpI links to Rfam database...	0.49	0.44	0.53	40	68560	36	15	20	1	50
PDB_00827	Intron_gpI links to Rfam database...	0.71	0.54	0.94	44	26981	5	0	3	2	37

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.