CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidFold		Carnac(seed)
MCC	0.565	>	0.000
Average MCC ± 95% Confidence Intervals	0.548 ± 0.052	>	0.000 ± 0.000
Sensitivity	0.517	>	0.000
Positive Predictive Value	0.618	>	0.000
Total TP	2365	>	0
Total TN	3422049	<	3425877
Total FP	1999	>	0
Total FP CONTRA	287	>	0
Total FP INCONS	1176	>	0
Total FP COMP	536	>	0
Total FN	2206	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidFold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Carnac(seed)).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	2365
Total TN	3422049
Total FP	1999
Total FP CONTRA	287
Total FP INCONS	1176
Total FP COMP	536
Total FN	2206

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.548 ± 0.052
Sensitivity	0.517
Positive Predictive Value	0.618
Nr of predictions	48

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.80	0.76	0.84	57	34123	16	2	9	5	18
ASE_00002	RNaseP_arch links to Rfam database...	0.59	0.55	0.63	40	35448	26	2	21	3	33
ASE_00009	RNaseP_arch links to Rfam database...	0.69	0.64	0.74	43	26048	16	0	15	1	24
ASE_00014	RNaseP_arch links to Rfam database...	0.56	0.53	0.60	56	54192	40	6	31	3	50
ASE_00116	RNaseP_arch links to Rfam database...	0.42	0.32	0.55	21	31588	20	0	17	3	45
ASE_00120	RNaseP_arch links to Rfam database...	0.66	0.55	0.79	52	46905	14	3	11	0	42
ASE_00121	RNaseP_arch links to Rfam database...	0.29	0.26	0.32	24	45074	53	5	47	1	68
ASE_00145	RNaseP_arch links to Rfam database...	0.58	0.56	0.61	62	70023	44	5	35	4	49
ASE_00148	RNaseP_arch links to Rfam database...	0.81	0.74	0.88	114	112445	19	4	12	3	40
ASE_00154	RNaseP_arch links to Rfam database...	0.73	0.67	0.78	72	65249	25	2	18	5	35
ASE_00155	RNaseP_arch links to Rfam database...	0.58	0.54	0.62	77	93403	51	6	42	3	65
ASE_00187	RNaseP_arch links to Rfam database...	0.44	0.37	0.53	42	68556	39	1	36	2	73
ASE_00196	RNaseP_arch links to Rfam database...	0.76	0.76	0.76	57	31551	21	2	16	3	18
ASE_00205	RNaseP_arch links to Rfam database...	0.48	0.46	0.50	41	45974	44	7	34	3	49
ASE_00209	RNaseP_arch links to Rfam database...	0.58	0.50	0.67	44	43005	22	2	20	0	44
ASE_00210	RNaseP_arch links to Rfam database...	0.65	0.65	0.65	42	27196	23	7	16	0	23
ASE_00213	RNaseP_arch links to Rfam database...	0.69	0.62	0.76	41	27207	13	4	9	0	25
ASE_00222	RNaseP_arch links to Rfam database...	0.74	0.70	0.79	110	111961	31	5	25	1	47
ASE_00346	RNaseP_arch links to Rfam database...	0.36	0.34	0.38	33	48119	56	3	50	3	64
ASE_00359	RNaseP_arch links to Rfam database...	0.50	0.45	0.55	36	42713	32	3	26	3	44
ASE_00360	RNaseP_arch links to Rfam database...	0.33	0.31	0.36	20	29347	37	8	28	1	45
ASE_00417	RNaseP_arch links to Rfam database...	0.52	0.47	0.57	47	54532	39	1	35	3	53
ASE_00418	RNaseP_arch links to Rfam database...	0.07	0.07	0.08	5	38722	56	1	53	2	70
CRW_00013	Intron_gpI links to Rfam database...	0.45	0.32	0.63	37	103681	42	7	15	20	78
CRW_00016	Intron_gpI links to Rfam database...	0.74	0.66	0.84	79	77327	27	0	15	12	41
CRW_00610	Intron_gpI links to Rfam database...	0.57	0.52	0.63	42	36248	26	7	18	1	39
CRW_00613	Intron_gpI links to Rfam database...	0.78	0.72	0.85	56	34914	17	1	9	7	22
CRW_00614	Intron_gpI links to Rfam database...	0.23	0.23	0.24	13	121716	103	6	36	61	44
CRW_00618	Intron_gpI links to Rfam database...	0.23	0.21	0.24	13	56226	58	6	35	17	48
CRW_00619	Intron_gpI links to Rfam database...	0.51	0.40	0.64	29	164980	90	3	13	74	44
CRW_00620	Intron_gpI links to Rfam database...	0.21	0.22	0.21	14	150907	85	15	39	31	49
CRW_00621	Intron_gpI links to Rfam database...	0.38	0.34	0.43	24	153125	120	5	27	88	47
CRW_00623	Intron_gpI links to Rfam database...	0.27	0.18	0.41	15	129758	64	3	19	42	68
CRW_00633	Intron_gpI links to Rfam database...	0.65	0.56	0.77	59	63469	20	2	16	2	47
CRW_00634	Intron_gpI links to Rfam database...	0.53	0.47	0.59	44	64546	31	11	19	1	50
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.63	0.93	76	70043	6	0	6	0	44
CRW_00671	Intron_gpI links to Rfam database...	0.71	0.64	0.78	75	62739	23	1	20	2	42
CRW_00672	Intron_gpI links to Rfam database...	0.58	0.49	0.70	54	72313	26	7	16	3	57
CRW_00674	Intron_gpI links to Rfam database...	0.71	0.63	0.80	78	83339	24	5	14	5	46
CRW_00676	Intron_gpI links to Rfam database...	0.47	0.46	0.48	53	93418	61	14	43	4	62
CRW_00692	Intron_gpI links to Rfam database...	0.49	0.44	0.53	40	68560	36	15	20	1	50
PDB_00827	Intron_gpI links to Rfam database...	0.71	0.54	0.94	44	26981	5	0	3	2	37
RFA_00597	Telomerase-vert links to Rfam database...	0.60	0.59	0.61	64	97798	56	15	26	15	45
RFA_00598	Telomerase-vert links to Rfam database...	0.48	0.47	0.51	47	84573	71	5	41	25	54
RFA_00599	Telomerase-vert links to Rfam database...	0.73	0.70	0.76	78	101372	49	7	18	24	33
RFA_00600	Telomerase-vert links to Rfam database...	0.68	0.72	0.64	72	120183	71	18	22	31	28
RFA_00601	Telomerase-vert links to Rfam database...	0.34	0.36	0.32	41	99105	97	33	56	8	73
RFA_00602	Telomerase-vert links to Rfam database...	0.67	0.71	0.64	82	101347	54	22	24	8	34

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]