CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & NanoFolder [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST NanoFolder
MCC 0.647 > 0.174
Average MCC ± 95% Confidence Intervals 0.636 ± 0.026 > 0.173 ± 0.022
Sensitivity 0.478 > 0.207
Positive Predictive Value 0.877 > 0.150
Total TP 5026 > 2176
Total TN 6500572 > 6491769
Total FP 971 < 12800
Total FP CONTRA 130 < 2292
Total FP INCONS 573 < 10064
Total FP COMP 268 < 444
Total FN 5486 < 8336
P-value 3.56938820447e-08

^top




Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and NanoFolder).

^top





Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 5026
Total TN 6500572
Total FP 971
Total FP CONTRA 130
Total FP INCONS 573
Total FP COMP 268
Total FN 5486
Total Scores
MCC 0.647
Average MCC ± 95% Confidence Intervals 0.636 ± 0.026
Sensitivity 0.478
Positive Predictive Value 0.877
Nr of predictions 103

^top



2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.56 0.38 0.83 24 51011 5 0 5 0 40
ASE_00083 0.72 0.56 0.93 62 62414 6 1 4 1 48
ASE_00122 0.78 0.61 1.00 54 43311 0 0 0 0 34
ASE_00185 0.62 0.41 0.95 52 73481 4 1 2 1 76
ASE_00190 0.46 0.23 0.91 21 45428 3 0 2 1 69
ASE_00196 0.65 0.47 0.90 35 31587 4 0 4 0 40
ASE_00221 0.75 0.61 0.93 71 64544 6 1 4 1 46
ASE_00227 0.41 0.18 0.92 24 78977 2 0 2 0 109
ASE_00228 0.79 0.69 0.92 59 46907 6 2 3 1 27
ASE_00229 0.79 0.69 0.90 60 42419 7 1 6 0 27
ASE_00231 0.76 0.63 0.92 60 47830 5 1 4 0 36
ASE_00234 0.61 0.42 0.90 54 75406 8 1 5 2 75
ASE_00238 0.57 0.37 0.89 42 64214 5 0 5 0 72
ASE_00248 0.82 0.71 0.94 81 62395 6 0 5 1 33
ASE_00250 0.70 0.50 1.00 65 78938 0 0 0 0 66
ASE_00254 0.84 0.74 0.95 61 36792 4 2 1 1 21
ASE_00255 0.73 0.57 0.94 74 74612 5 0 5 0 56
ASE_00257 0.82 0.68 0.99 66 50973 2 0 1 1 31
ASE_00267 0.72 0.66 0.79 58 45077 17 2 13 2 30
ASE_00270 0.52 0.27 1.00 35 72355 0 0 0 0 93
ASE_00274 0.66 0.47 0.92 48 55559 5 0 4 1 55
ASE_00277 0.64 0.56 0.74 51 48136 21 3 15 3 40
ASE_00279 0.72 0.58 0.89 59 53235 8 3 4 1 42
ASE_00285 0.63 0.44 0.89 54 68945 8 3 4 1 68
ASE_00287 0.66 0.49 0.91 50 54891 6 0 5 1 53
ASE_00294 0.75 0.60 0.94 103 114372 8 1 5 2 68
ASE_00295 0.70 0.54 0.91 71 73842 8 1 6 1 60
ASE_00298 0.62 0.39 1.00 44 67484 1 0 0 1 69
ASE_00318 0.55 0.35 0.87 41 80153 12 0 6 6 77
ASE_00335 0.80 0.66 0.97 76 75388 8 0 2 6 40
ASE_00339 0.79 0.64 0.97 76 80122 8 0 2 6 43
ASE_00340 0.63 0.48 0.84 41 46007 11 6 2 3 44
ASE_00343 0.73 0.61 0.88 69 83358 16 0 9 7 44
ASE_00367 0.78 0.70 0.87 60 43002 11 1 8 2 26
ASE_00370 0.78 0.67 0.90 56 41843 7 1 5 1 28
ASE_00372 0.70 0.54 0.90 54 51943 6 3 3 0 46
ASE_00375 0.71 0.50 1.00 55 60323 0 0 0 0 55
ASE_00376 0.65 0.51 0.83 54 56888 15 0 11 4 51
ASE_00377 0.75 0.62 0.92 66 57558 7 0 6 1 41
ASE_00386 0.70 0.56 0.87 54 50341 9 1 7 1 42
ASE_00393 0.70 0.57 0.87 53 47834 9 1 7 1 40
ASE_00412 0.62 0.40 0.98 42 58268 3 0 1 2 63
ASE_00413 0.72 0.54 0.96 44 44505 2 0 2 0 37
ASE_00416 0.58 0.36 0.92 46 77371 5 1 3 1 81
ASE_00417 0.51 0.43 0.61 43 54545 28 1 26 1 57
ASE_00422 0.72 0.55 0.95 52 46916 4 0 3 1 42
ASE_00428 0.60 0.39 0.91 49 76582 6 1 4 1 76
ASE_00429 - 0.68 0.56 0.82 37 28158 12 1 7 4 29
ASE_00430 0.77 0.61 0.98 59 46911 3 0 1 2 38
ASE_00434 0.50 0.26 0.94 29 68234 2 0 2 0 81
ASE_00437 0.55 0.47 0.66 63 79305 35 1 32 2 72
ASE_00451 0.77 0.72 0.83 90 70768 20 1 17 2 35
CRW_00654 - 0.76 0.60 0.95 75 78131 6 1 3 2 49
CRW_00658 - 0.64 0.44 0.94 45 74643 3 0 3 0 57
CRW_00663 - 0.24 0.18 0.32 11 26072 23 1 22 0 50
CRW_00664 - 0.28 0.22 0.35 17 53580 34 2 29 3 61
CRW_00671 0.66 0.48 0.92 56 62774 5 1 4 0 61
CRW_00672 0.69 0.50 0.96 55 72333 3 0 2 1 56
CRW_00674 0.76 0.57 1.00 71 83365 1 0 0 1 53
CRW_00676 0.73 0.55 0.98 63 93464 3 0 1 2 52
CRW_00688 - 0.84 0.81 0.87 46 21892 8 2 5 1 11
CRW_00721 - 0.54 0.29 1.00 20 58633 0 0 0 0 48
PDB_00078 - 0.68 0.56 0.83 64 49693 13 4 9 0 51
PDB_00278 - 0.43 0.21 0.88 15 24959 2 0 2 0 57
PDB_00701 - 0.34 0.15 0.80 16 45431 5 0 4 1 93
PDB_00917 - 0.54 0.31 0.97 29 35215 5 0 1 4 66
TMR_00036 0.66 0.44 1.00 44 90481 5 0 0 5 57
TMR_00123 0.69 0.55 0.86 56 66365 14 0 9 5 45
TMR_00180 0.79 0.71 0.89 70 67082 21 3 6 12 29
TMR_00240 0.60 0.40 0.89 34 63152 7 1 3 3 51
TMR_00352 0.42 0.29 0.61 22 95230 36 3 11 22 53
TMR_00353 0.50 0.25 1.00 26 84229 0 0 0 0 79
TMR_00357 0.44 0.23 0.84 21 83003 4 0 4 0 71
TMR_00361 - 0.37 0.35 0.40 25 93465 45 16 22 7 47
TMR_00374 0.48 0.26 0.89 24 81783 3 1 2 0 68
TMR_00384 0.76 0.61 0.96 66 65634 8 0 3 5 42
TMR_00395 0.76 0.63 0.92 69 64545 10 2 4 4 40
TMR_00398 0.79 0.67 0.93 71 65265 9 1 4 4 35
TMR_00399 0.45 0.31 0.66 29 64936 25 7 8 10 65
TMR_00430 0.42 0.25 0.73 27 82584 12 0 10 2 82
TMR_00431 0.56 0.31 1.00 17 51986 0 0 0 0 38
TMR_00443 0.69 0.55 0.86 57 67095 13 1 8 4 47
TMR_00457 0.69 0.58 0.82 59 78534 17 3 10 4 43
TMR_00469 0.79 0.70 0.90 70 64542 11 4 4 3 30
TMR_00502 0.49 0.37 0.65 34 75414 26 6 12 8 59
TMR_00503 0.49 0.24 1.00 27 67869 7 0 0 7 84
TMR_00519 0.61 0.46 0.80 44 63135 20 2 9 9 51
TMR_00528 0.60 0.46 0.78 45 63132 22 4 9 9 52
TMR_00541 0.52 0.27 1.00 28 61748 5 0 0 5 77
TMR_00547 0.68 0.52 0.90 52 65283 8 0 6 2 48
TMR_00562 0.68 0.56 0.83 57 72702 17 6 6 5 45
TMR_00566 0.69 0.54 0.89 54 60665 14 1 6 7 46
TMR_00571 0.66 0.49 0.89 49 60671 14 1 5 8 50
TMR_00584 0.72 0.57 0.92 55 61015 13 1 4 8 42
TMR_00594 0.61 0.47 0.79 49 79339 16 2 11 3 55
TMR_00605 0.64 0.50 0.83 54 74240 15 2 9 4 54
TMR_00609 0.76 0.65 0.89 74 63463 9 1 8 0 39
TMR_00624 0.42 0.18 1.00 19 62462 1 0 0 1 89
TMR_00683 0.41 0.18 0.95 18 83009 5 1 0 4 82
TMR_00698 0.46 0.28 0.76 29 63152 9 1 8 0 75
TMR_00703 0.78 0.66 0.92 65 67457 11 1 5 5 34
TMR_00706 0.46 0.21 1.00 22 66408 0 0 0 0 81
TMR_00711 0.53 0.35 0.81 34 67854 9 6 2 1 64

^top



Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 2176
Total TN 6491769
Total FP 12800
Total FP CONTRA 2292
Total FP INCONS 10064
Total FP COMP 444
Total FN 8336
Total Scores
MCC 0.174
Average MCC ± 95% Confidence Intervals 0.173 ± 0.022
Sensitivity 0.207
Positive Predictive Value 0.150
Nr of predictions 103

^top



2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.02 0.03 0.02 2 50914 131 38 86 7 62
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00122 0.27 0.30 0.24 26 43258 84 13 68 3 62
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00196 0.49 0.57 0.42 43 31524 62 16 43 3 32
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00227 0.28 0.31 0.25 41 78840 122 20 102 0 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00250 0.25 0.29 0.23 38 78835 135 17 113 5 93
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00295 0.14 0.16 0.13 21 73761 140 19 119 2 110
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00339 0.25 0.29 0.22 34 80042 129 20 104 5 85
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00343 0.14 0.17 0.12 19 83275 145 31 111 3 94
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00375 0.12 0.14 0.11 15 60246 120 10 107 3 95
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00417 0.32 0.36 0.28 36 54486 98 18 75 5 64
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00429 - 0.08 0.09 0.07 6 28114 84 14 69 1 60
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00434 0.29 0.34 0.25 37 68116 122 20 92 10 73
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_00654 - 0.41 0.47 0.36 58 78049 105 18 85 2 66
CRW_00658 - 0.21 0.26 0.16 27 74527 137 28 109 0 75
CRW_00663 - 0.08 0.10 0.07 6 26014 90 17 69 4 55
CRW_00664 - 0.14 0.19 0.11 15 53486 134 42 85 7 63
CRW_00671 0.18 0.21 0.16 24 62682 130 23 106 1 93
CRW_00672 0.36 0.43 0.31 48 72233 114 35 74 5 63
CRW_00674 0.16 0.19 0.14 23 83274 142 19 120 3 101
CRW_00676 0.11 0.14 0.09 16 93347 169 29 136 4 99
CRW_00688 - 0.33 0.40 0.27 23 21859 64 21 42 1 34
CRW_00721 - 0.22 0.31 0.15 21 58515 133 46 71 16 47
PDB_00078 - 0.00 0.00 0.00 0 49644 126 10 116 0 115
PDB_00278 - 0.04 0.06 0.04 4 24875 98 13 84 1 68
PDB_00701 - 0.04 0.05 0.04 5 45319 127 14 113 0 104
PDB_00917 - 0.31 0.34 0.29 32 35136 81 10 67 4 63
TMR_00036 0.22 0.29 0.17 29 90359 153 37 100 16 72
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00180 0.12 0.16 0.10 16 66999 149 35 111 3 83
TMR_00240 0.23 0.31 0.17 26 63041 128 39 84 5 59
TMR_00352 0.07 0.09 0.05 7 95133 171 39 87 45 68
TMR_00353 0.41 0.51 0.32 54 84087 127 49 65 13 51
TMR_00357 0.26 0.34 0.19 31 82869 146 44 84 18 61
TMR_00361 - 0.06 0.10 0.04 7 93368 174 64 89 21 65
TMR_00374 0.09 0.13 0.07 12 81631 174 44 123 7 80
TMR_00384 0.17 0.20 0.14 22 65550 133 26 105 2 86
TMR_00395 0.27 0.31 0.24 34 64478 115 10 98 7 75
TMR_00398 0.05 0.07 0.05 7 65197 139 24 113 2 99
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00430 0.18 0.23 0.15 25 82450 148 34 112 2 84
TMR_00431 0.24 0.33 0.17 18 51899 127 26 60 41 37
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00457 0.19 0.25 0.15 25 78443 141 39 99 3 77
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00502 0.14 0.19 0.11 18 75303 150 45 100 5 75
TMR_00503 0.11 0.14 0.10 15 67741 141 20 120 1 96
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00541 0.12 0.14 0.10 15 61630 139 22 109 8 90
TMR_00547 0.28 0.35 0.23 35 65188 122 37 81 4 65
TMR_00562 0.09 0.12 0.08 12 72617 147 27 115 5 90
TMR_00566 0.13 0.16 0.11 16 60582 132 22 106 4 84
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96
TMR_00594 0.08 0.10 0.06 10 79238 156 30 123 3 94
TMR_00605 0.28 0.35 0.23 38 74141 129 36 90 3 70
TMR_00609 0.53 0.62 0.45 70 63391 89 28 57 4 43
TMR_00624 0.36 0.44 0.30 47 62325 111 27 82 2 61
TMR_00683 0.01 0.02 0.01 2 82854 176 50 122 4 98
TMR_00698 0.20 0.24 0.17 25 63042 124 27 96 1 79
TMR_00703 0.10 0.12 0.08 12 67376 140 26 114 0 87
TMR_00706 0.14 0.17 0.11 17 66281 133 29 103 1 86
TMR_00711 0.18 0.22 0.14 22 67740 137 41 93 3 76

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.