CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Contrafold		CMfinder(seed)
MCC	0.576	>	0.350
Average MCC ± 95% Confidence Intervals	0.561 ± 0.105	>	0.358 ± 0.060
Sensitivity	0.556	>	0.159
Positive Predictive Value	0.597	<	0.770
Total TP	817	>	234
Total TN	1035282	<	1036346
Total FP	737	>	77
Total FP CONTRA	106	>	3
Total FP INCONS	445	>	67
Total FP COMP	186	>	7
Total FN	653	<	1236
P-value	2.32677072069e-08

Comparison of performance of Contrafold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and CMfinder(seed)).

Total Scores
MCC	0.576
Average MCC ± 95% Confidence Intervals	0.561 ± 0.105
Sensitivity	0.556
Positive Predictive Value	0.597
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.43	0.39	0.47	45	103644	80	11	40	29	70
CRW_00016	Intron_gpI links to Rfam database...	0.73	0.68	0.79	81	77319	37	0	21	16	39
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.49	0.51	40	36237	41	9	29	3	41
CRW_00613	Intron_gpI links to Rfam database...	0.79	0.77	0.81	60	34906	22	1	13	8	18
CRW_00614	Intron_gpI links to Rfam database...	0.24	0.25	0.23	14	121709	121	7	41	73	43
CRW_00618	Intron_gpI links to Rfam database...	0.20	0.21	0.19	13	56213	75	8	46	21	48
CRW_00633	Intron_gpI links to Rfam database...	0.58	0.55	0.62	58	63453	37	8	27	2	48
CRW_00634	Intron_gpI links to Rfam database...	0.58	0.59	0.57	55	64524	43	12	29	2	39
CRW_00670	Intron_gpI links to Rfam database...	0.76	0.71	0.83	85	70022	19	0	18	1	35
CRW_00671	Intron_gpI links to Rfam database...	0.73	0.70	0.77	82	62728	31	1	24	6	35
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.52	0.55	58	72284	55	8	40	7	53
CRW_00674	Intron_gpI links to Rfam database...	0.70	0.66	0.74	82	83325	34	5	24	5	42
CRW_00676	Intron_gpI links to Rfam database...	0.42	0.44	0.40	51	93400	81	20	57	4	64
CRW_00692	Intron_gpI links to Rfam database...	0.45	0.44	0.47	40	68549	53	16	30	7	50
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.90	53	26969	8	0	6	2	28

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.