CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Contrafold		Carnac(seed)
MCC	0.546	>	0.000
Average MCC ± 95% Confidence Intervals	0.530 ± 0.053	>	0.000 ± 0.000
Sensitivity	0.537	>	0.000
Positive Predictive Value	0.556	>	0.000
Total TP	2455	>	0
Total TN	3421459	<	3425877
Total FP	2687	>	0
Total FP CONTRA	360	>	0
Total FP INCONS	1603	>	0
Total FP COMP	724	>	0
Total FN	2116	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Contrafold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP	2455
Total TN	3421459
Total FP	2687
Total FP CONTRA	360
Total FP INCONS	1603
Total FP COMP	724
Total FN	2116

Total Scores
MCC	0.546
Average MCC ± 95% Confidence Intervals	0.530 ± 0.053
Sensitivity	0.537
Positive Predictive Value	0.556
Nr of predictions	48

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.80	0.77	0.83	58	34121	21	3	9	9	17
ASE_00002	RNaseP_arch links to Rfam database...	0.59	0.56	0.61	41	35444	30	2	24	4	32
ASE_00009	RNaseP_arch links to Rfam database...	0.66	0.64	0.68	43	26043	23	1	19	3	24
ASE_00014	RNaseP_arch links to Rfam database...	0.53	0.53	0.53	56	54179	54	6	44	4	50
ASE_00116	RNaseP_arch links to Rfam database...	0.46	0.42	0.50	28	31570	31	0	28	3	38
ASE_00120	RNaseP_arch links to Rfam database...	0.60	0.57	0.64	54	46886	31	6	25	0	40
ASE_00121	RNaseP_arch links to Rfam database...	0.28	0.27	0.29	25	45063	64	6	56	2	67
ASE_00145	RNaseP_arch links to Rfam database...	0.60	0.59	0.60	66	70015	50	7	37	6	45
ASE_00148	RNaseP_arch links to Rfam database...	0.79	0.78	0.81	120	112426	34	5	24	5	34
ASE_00154	RNaseP_arch links to Rfam database...	0.74	0.72	0.76	77	65240	31	2	22	7	30
ASE_00155	RNaseP_arch links to Rfam database...	0.60	0.58	0.61	83	93392	56	4	49	3	59
ASE_00187	RNaseP_arch links to Rfam database...	0.38	0.37	0.40	42	68531	68	5	57	6	73
ASE_00196	RNaseP_arch links to Rfam database...	0.75	0.76	0.74	57	31549	26	2	18	6	18
ASE_00205	RNaseP_arch links to Rfam database...	0.45	0.46	0.45	41	45964	60	7	44	9	49
ASE_00209	RNaseP_arch links to Rfam database...	0.56	0.51	0.61	45	42997	31	3	26	2	43
ASE_00210	RNaseP_arch links to Rfam database...	0.58	0.60	0.57	39	27192	31	7	23	1	26
ASE_00213	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	38	27196	30	5	22	3	28
ASE_00222	RNaseP_arch links to Rfam database...	0.72	0.71	0.74	111	111950	46	7	33	6	46
ASE_00346	RNaseP_arch links to Rfam database...	0.34	0.34	0.35	33	48111	67	4	57	6	64
ASE_00359	RNaseP_arch links to Rfam database...	0.49	0.48	0.51	38	42703	44	3	34	7	42
ASE_00360	RNaseP_arch links to Rfam database...	0.31	0.31	0.32	20	29341	43	8	34	1	45
ASE_00417	RNaseP_arch links to Rfam database...	0.47	0.47	0.47	47	54516	55	2	50	3	53
ASE_00418	RNaseP_arch links to Rfam database...	0.06	0.07	0.07	5	38706	72	5	65	2	70
CRW_00013	Intron_gpI links to Rfam database...	0.43	0.39	0.47	45	103644	80	11	40	29	70
CRW_00016	Intron_gpI links to Rfam database...	0.73	0.68	0.79	81	77319	37	0	21	16	39
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.49	0.51	40	36237	41	9	29	3	41
CRW_00613	Intron_gpI links to Rfam database...	0.79	0.77	0.81	60	34906	22	1	13	8	18
CRW_00614	Intron_gpI links to Rfam database...	0.24	0.25	0.23	14	121709	121	7	41	73	43
CRW_00618	Intron_gpI links to Rfam database...	0.20	0.21	0.19	13	56213	75	8	46	21	48
CRW_00619	Intron_gpI links to Rfam database...	0.45	0.40	0.52	29	164969	110	5	22	83	44
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.22	0.15	14	150884	136	23	54	59	49
CRW_00621	Intron_gpI links to Rfam database...	0.37	0.35	0.38	25	153116	137	6	34	97	46
CRW_00623	Intron_gpI links to Rfam database...	0.25	0.20	0.31	17	129740	100	5	33	62	66
CRW_00633	Intron_gpI links to Rfam database...	0.58	0.55	0.62	58	63453	37	8	27	2	48
CRW_00634	Intron_gpI links to Rfam database...	0.58	0.59	0.57	55	64524	43	12	29	2	39
CRW_00670	Intron_gpI links to Rfam database...	0.76	0.71	0.83	85	70022	19	0	18	1	35
CRW_00671	Intron_gpI links to Rfam database...	0.73	0.70	0.77	82	62728	31	1	24	6	35
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.52	0.55	58	72284	55	8	40	7	53
CRW_00674	Intron_gpI links to Rfam database...	0.70	0.66	0.74	82	83325	34	5	24	5	42
CRW_00676	Intron_gpI links to Rfam database...	0.42	0.44	0.40	51	93400	81	20	57	4	64
CRW_00692	Intron_gpI links to Rfam database...	0.45	0.44	0.47	40	68549	53	16	30	7	50
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.90	53	26969	8	0	6	2	28
RFA_00597	Telomerase-vert links to Rfam database...	0.60	0.61	0.59	67	97789	69	16	31	22	42
RFA_00598	Telomerase-vert links to Rfam database...	0.47	0.47	0.48	47	84569	79	6	44	29	54
RFA_00599	Telomerase-vert links to Rfam database...	0.71	0.73	0.70	81	101359	59	10	25	24	30
RFA_00600	Telomerase-vert links to Rfam database...	0.67	0.72	0.62	72	120178	86	21	24	41	28
RFA_00601	Telomerase-vert links to Rfam database...	0.33	0.36	0.30	41	99097	108	37	60	11	73
RFA_00602	Telomerase-vert links to Rfam database...	0.63	0.67	0.58	78	101341	68	25	31	12	38

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

2. Individual counts for Contrafold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]