CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	MaxExpect		CMfinder(seed)
MCC	0.559	>	0.350
Average MCC ± 95% Confidence Intervals	0.543 ± 0.119	>	0.358 ± 0.060
Sensitivity	0.543	>	0.159
Positive Predictive Value	0.576	<	0.770
Total TP	798	>	234
Total TN	1035265	<	1036346
Total FP	762	>	77
Total FP CONTRA	115	>	3
Total FP INCONS	472	>	67
Total FP COMP	175	>	7
Total FN	672	<	1236
P-value	1.87872347734e-08

Comparison of performance of MaxExpect and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).

Total Scores
MCC	0.559
Average MCC ± 95% Confidence Intervals	0.543 ± 0.119
Sensitivity	0.543
Positive Predictive Value	0.576
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.42	0.37	0.47	43	103648	69	4	45	20	72
CRW_00016	Intron_gpI links to Rfam database...	0.51	0.47	0.57	56	77322	56	6	37	13	64
CRW_00610	Intron_gpI links to Rfam database...	0.46	0.46	0.47	37	36237	41	7	34	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.85	0.82	0.89	64	34908	16	0	8	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121696	125	18	48	59	48
CRW_00618	Intron_gpI links to Rfam database...	0.19	0.20	0.19	12	56217	69	7	44	18	49
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.57	0.67	60	63457	32	8	21	3	46
CRW_00634	Intron_gpI links to Rfam database...	0.48	0.47	0.49	44	64531	49	9	36	4	50
CRW_00670	Intron_gpI links to Rfam database...	0.56	0.58	0.56	69	70001	57	12	43	2	51
CRW_00671	Intron_gpI links to Rfam database...	0.80	0.76	0.85	89	62730	20	1	15	4	28
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.77	0.78	86	72280	32	6	18	8	25
CRW_00674	Intron_gpI links to Rfam database...	0.63	0.61	0.64	76	83318	45	8	34	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.60	0.60	69	93413	64	12	34	18	46
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	80	17	50	13	59
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.91	53	26970	7	0	5	2	28

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.