CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MaxExpect		Carnac(seed)
MCC	0.516	>	0.000
Average MCC ± 95% Confidence Intervals	0.503 ± 0.055	>	0.000 ± 0.000
Sensitivity	0.509	>	0.000
Positive Predictive Value	0.525	>	0.000
Total TP	2326	>	0
Total TN	3421447	<	3425877
Total FP	2814	>	0
Total FP CONTRA	371	>	0
Total FP INCONS	1733	>	0
Total FP COMP	710	>	0
Total FN	2245	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MaxExpect and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP	2326
Total TN	3421447
Total FP	2814
Total FP CONTRA	371
Total FP INCONS	1733
Total FP COMP	710
Total FN	2245

Total Scores
MCC	0.516
Average MCC ± 95% Confidence Intervals	0.503 ± 0.055
Sensitivity	0.509
Positive Predictive Value	0.525
Nr of predictions	48

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.63	0.61	0.66	46	34121	30	2	22	6	29
ASE_00002	RNaseP_arch links to Rfam database...	0.71	0.67	0.74	49	35445	20	2	15	3	24
ASE_00009	RNaseP_arch links to Rfam database...	0.36	0.34	0.38	23	26045	39	4	34	1	44
ASE_00014	RNaseP_arch links to Rfam database...	0.42	0.42	0.44	44	54184	65	2	55	8	62
ASE_00116	RNaseP_arch links to Rfam database...	0.32	0.30	0.34	20	31567	42	4	35	3	46
ASE_00120	RNaseP_arch links to Rfam database...	0.59	0.54	0.65	51	46892	30	3	25	2	43
ASE_00121	RNaseP_arch links to Rfam database...	0.25	0.25	0.25	23	45059	70	6	62	2	69
ASE_00145	RNaseP_arch links to Rfam database...	0.58	0.57	0.59	63	70018	48	4	40	4	48
ASE_00148	RNaseP_arch links to Rfam database...	0.71	0.69	0.72	107	112427	45	3	38	4	47
ASE_00154	RNaseP_arch links to Rfam database...	0.58	0.58	0.58	62	65234	49	4	41	4	45
ASE_00155	RNaseP_arch links to Rfam database...	0.53	0.51	0.54	73	93394	64	10	51	3	69
ASE_00187	RNaseP_arch links to Rfam database...	0.40	0.38	0.43	44	68532	66	6	53	7	71
ASE_00196	RNaseP_arch links to Rfam database...	0.78	0.77	0.79	58	31553	19	2	13	4	17
ASE_00205	RNaseP_arch links to Rfam database...	0.62	0.62	0.62	56	45965	39	7	28	4	34
ASE_00209	RNaseP_arch links to Rfam database...	0.40	0.39	0.43	34	42991	46	5	41	0	54
ASE_00210	RNaseP_arch links to Rfam database...	0.65	0.66	0.64	43	27194	24	6	18	0	22
ASE_00213	RNaseP_arch links to Rfam database...	0.72	0.71	0.73	47	27197	20	3	14	3	19
ASE_00222	RNaseP_arch links to Rfam database...	0.58	0.56	0.60	88	111955	58	4	54	0	69
ASE_00346	RNaseP_arch links to Rfam database...	0.43	0.41	0.45	40	48117	56	4	44	8	57
ASE_00359	RNaseP_arch links to Rfam database...	0.25	0.24	0.26	19	42704	55	5	50	0	61
ASE_00360	RNaseP_arch links to Rfam database...	0.29	0.28	0.31	18	29344	46	9	32	5	47
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.35	37	54510	69	9	59	1	63
ASE_00418	RNaseP_arch links to Rfam database...	0.19	0.20	0.19	15	38702	67	8	56	3	60
CRW_00013	Intron_gpI links to Rfam database...	0.42	0.37	0.47	43	103648	69	4	45	20	72
CRW_00016	Intron_gpI links to Rfam database...	0.51	0.47	0.57	56	77322	56	6	37	13	64
CRW_00610	Intron_gpI links to Rfam database...	0.46	0.46	0.47	37	36237	41	7	34	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.85	0.82	0.89	64	34908	16	0	8	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121696	125	18	48	59	48
CRW_00618	Intron_gpI links to Rfam database...	0.19	0.20	0.19	12	56217	69	7	44	18	49
CRW_00619	Intron_gpI links to Rfam database...	0.36	0.37	0.35	27	164947	145	7	44	94	46
CRW_00620	Intron_gpI links to Rfam database...	0.18	0.21	0.15	13	150890	150	18	54	78	50
CRW_00621	Intron_gpI links to Rfam database...	0.38	0.35	0.42	25	153121	125	6	29	90	46
CRW_00623	Intron_gpI links to Rfam database...	0.32	0.29	0.35	24	129727	109	5	39	65	59
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.57	0.67	60	63457	32	8	21	3	46
CRW_00634	Intron_gpI links to Rfam database...	0.48	0.47	0.49	44	64531	49	9	36	4	50
CRW_00670	Intron_gpI links to Rfam database...	0.56	0.58	0.56	69	70001	57	12	43	2	51
CRW_00671	Intron_gpI links to Rfam database...	0.80	0.76	0.85	89	62730	20	1	15	4	28
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.77	0.78	86	72280	32	6	18	8	25
CRW_00674	Intron_gpI links to Rfam database...	0.63	0.61	0.64	76	83318	45	8	34	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.60	0.60	69	93413	64	12	34	18	46
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	80	17	50	13	59
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.91	53	26970	7	0	5	2	28
RFA_00597	Telomerase-vert links to Rfam database...	0.24	0.26	0.23	28	97782	106	20	73	13	81
RFA_00598	Telomerase-vert links to Rfam database...	0.66	0.63	0.68	64	84572	59	3	27	29	37
RFA_00599	Telomerase-vert links to Rfam database...	0.72	0.72	0.71	80	101363	56	10	22	24	31
RFA_00600	Telomerase-vert links to Rfam database...	0.62	0.69	0.55	69	120170	89	30	26	33	31
RFA_00601	Telomerase-vert links to Rfam database...	0.49	0.52	0.46	59	99108	82	28	40	14	55
RFA_00602	Telomerase-vert links to Rfam database...	0.66	0.68	0.64	79	101352	64	17	27	20	37

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

2. Individual counts for MaxExpect [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]