CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	McQFold		CMfinder(seed)
MCC	0.472	>	0.350
Average MCC ± 95% Confidence Intervals	0.472 ± 0.123	>	0.358 ± 0.060
Sensitivity	0.456	>	0.159
Positive Predictive Value	0.489	<	0.770
Total TP	670	>	234
Total TN	1035281	<	1036346
Total FP	839	>	77
Total FP CONTRA	153	>	3
Total FP INCONS	546	>	67
Total FP COMP	140	>	7
Total FN	800	<	1236
P-value	2.7402423548e-08

Comparison of performance of McQFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).

Total Scores
MCC	0.472
Average MCC ± 95% Confidence Intervals	0.472 ± 0.123
Sensitivity	0.456
Positive Predictive Value	0.489
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.10	0.10	0.11	11	103641	107	9	79	19	104
CRW_00016	Intron_gpI links to Rfam database...	0.66	0.61	0.72	73	77320	38	5	23	10	47
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.48	0.51	39	36239	38	6	31	1	42
CRW_00613	Intron_gpI links to Rfam database...	0.81	0.73	0.89	57	34916	15	0	7	8	21
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	132	26	51	55	52
CRW_00618	Intron_gpI links to Rfam database...	0.37	0.39	0.34	24	56210	60	15	31	14	37
CRW_00633	Intron_gpI links to Rfam database...	0.74	0.72	0.77	76	63447	26	8	15	3	30
CRW_00634	Intron_gpI links to Rfam database...	0.44	0.41	0.47	39	64537	48	18	26	4	55
CRW_00670	Intron_gpI links to Rfam database...	0.54	0.53	0.55	63	70011	53	6	45	2	57
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.59	0.74	69	62742	28	5	19	4	48
CRW_00672	Intron_gpI links to Rfam database...	0.52	0.50	0.56	55	72291	48	9	35	4	56
CRW_00674	Intron_gpI links to Rfam database...	0.43	0.42	0.44	52	83319	69	14	51	4	72
CRW_00676	Intron_gpI links to Rfam database...	0.30	0.30	0.31	35	93414	85	9	70	6	80
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.27	0.25	24	68538	77	23	50	4	66
PDB_00827	Intron_gpI links to Rfam database...	0.68	0.59	0.79	48	26967	15	0	13	2	33

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.