CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	McQFold		Carnac(seed)
MCC	0.448	>	0.000
Average MCC ± 95% Confidence Intervals	0.450 ± 0.063	>	0.000 ± 0.000
Sensitivity	0.441	>	0.000
Positive Predictive Value	0.457	>	0.000
Total TP	2015	>	0
Total TN	3421470	<	3425877
Total FP	2914	>	0
Total FP CONTRA	427	>	0
Total FP INCONS	1965	>	0
Total FP COMP	522	>	0
Total FN	2556	<	4571
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of McQFold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Carnac(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	2015
Total TN	3421470
Total FP	2914
Total FP CONTRA	427
Total FP INCONS	1965
Total FP COMP	522
Total FN	2556

Total Scores
MCC	0.448
Average MCC ± 95% Confidence Intervals	0.450 ± 0.063
Sensitivity	0.441
Positive Predictive Value	0.457
Nr of predictions	48

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.78	0.73	0.82	55	34124	17	7	5	5	20
ASE_00002	RNaseP_arch links to Rfam database...	0.80	0.75	0.86	55	35447	12	4	5	3	18
ASE_00009	RNaseP_arch links to Rfam database...	0.67	0.64	0.70	43	26045	18	3	15	0	24
ASE_00014	RNaseP_arch links to Rfam database...	0.47	0.47	0.48	50	54180	56	9	46	1	56
ASE_00116	RNaseP_arch links to Rfam database...	0.52	0.50	0.54	33	31565	32	3	25	4	33
ASE_00120	RNaseP_arch links to Rfam database...	0.47	0.46	0.49	43	46883	45	4	41	0	51
ASE_00121	RNaseP_arch links to Rfam database...	0.47	0.46	0.48	42	45063	47	7	38	2	50
ASE_00145	RNaseP_arch links to Rfam database...	0.52	0.50	0.54	56	70022	50	2	45	3	55
ASE_00148	RNaseP_arch links to Rfam database...	0.64	0.62	0.66	96	112430	49	4	45	0	58
ASE_00154	RNaseP_arch links to Rfam database...	0.62	0.61	0.64	65	65239	37	1	36	0	42
ASE_00155	RNaseP_arch links to Rfam database...	0.59	0.56	0.62	80	93398	54	3	47	4	62
ASE_00187	RNaseP_arch links to Rfam database...	0.51	0.48	0.56	55	68536	48	3	41	4	60
ASE_00196	RNaseP_arch links to Rfam database...	0.78	0.75	0.81	56	31557	16	2	11	3	19
ASE_00205	RNaseP_arch links to Rfam database...	0.52	0.52	0.53	47	45967	45	10	32	3	43
ASE_00209	RNaseP_arch links to Rfam database...	0.62	0.58	0.66	51	42994	26	4	22	0	37
ASE_00210	RNaseP_arch links to Rfam database...	0.57	0.55	0.58	36	27199	28	6	20	2	29
ASE_00213	RNaseP_arch links to Rfam database...	0.71	0.70	0.73	46	27198	18	4	13	1	20
ASE_00222	RNaseP_arch links to Rfam database...	0.52	0.50	0.55	78	111958	65	5	60	0	79
ASE_00346	RNaseP_arch links to Rfam database...	0.38	0.36	0.41	35	48120	53	4	46	3	62
ASE_00359	RNaseP_arch links to Rfam database...	0.11	0.10	0.12	8	42711	62	2	57	3	72
ASE_00360	RNaseP_arch links to Rfam database...	0.40	0.37	0.44	24	29348	31	3	28	0	41
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.36	37	54512	68	9	57	2	63
ASE_00418	RNaseP_arch links to Rfam database...	0.12	0.12	0.12	9	38703	71	10	59	2	66
CRW_00013	Intron_gpI links to Rfam database...	0.10	0.10	0.11	11	103641	107	9	79	19	104
CRW_00016	Intron_gpI links to Rfam database...	0.66	0.61	0.72	73	77320	38	5	23	10	47
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.48	0.51	39	36239	38	6	31	1	42
CRW_00613	Intron_gpI links to Rfam database...	0.81	0.73	0.89	57	34916	15	0	7	8	21
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	132	26	51	55	52
CRW_00618	Intron_gpI links to Rfam database...	0.37	0.39	0.34	24	56210	60	15	31	14	37
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	164963	138	7	55	76	73
CRW_00620	Intron_gpI links to Rfam database...	0.19	0.21	0.18	13	150901	128	14	47	67	50
CRW_00621	Intron_gpI links to Rfam database...	0.28	0.25	0.30	18	153121	121	12	30	79	53
CRW_00623	Intron_gpI links to Rfam database...	0.12	0.13	0.11	11	129696	122	21	67	34	72
CRW_00633	Intron_gpI links to Rfam database...	0.74	0.72	0.77	76	63447	26	8	15	3	30
CRW_00634	Intron_gpI links to Rfam database...	0.44	0.41	0.47	39	64537	48	18	26	4	55
CRW_00670	Intron_gpI links to Rfam database...	0.54	0.53	0.55	63	70011	53	6	45	2	57
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.59	0.74	69	62742	28	5	19	4	48
CRW_00672	Intron_gpI links to Rfam database...	0.52	0.50	0.56	55	72291	48	9	35	4	56
CRW_00674	Intron_gpI links to Rfam database...	0.43	0.42	0.44	52	83319	69	14	51	4	72
CRW_00676	Intron_gpI links to Rfam database...	0.30	0.30	0.31	35	93414	85	9	70	6	80
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.27	0.25	24	68538	77	23	50	4	66
PDB_00827	Intron_gpI links to Rfam database...	0.68	0.59	0.79	48	26967	15	0	13	2	33
RFA_00597	Telomerase-vert links to Rfam database...	0.34	0.37	0.31	40	97776	101	20	67	14	69
RFA_00598	Telomerase-vert links to Rfam database...	0.35	0.36	0.35	36	84563	76	12	55	9	65
RFA_00599	Telomerase-vert links to Rfam database...	0.39	0.40	0.38	44	101359	92	13	59	20	67
RFA_00600	Telomerase-vert links to Rfam database...	0.18	0.21	0.16	21	120164	129	29	81	19	79
RFA_00601	Telomerase-vert links to Rfam database...	0.09	0.10	0.08	11	99104	129	18	102	9	103
RFA_00602	Telomerase-vert links to Rfam database...	0.41	0.44	0.39	51	101343	91	19	62	10	65

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	0
Total TN	3425877
Total FP	0
Total FP CONTRA	0
Total FP INCONS	0
Total FP COMP	0
Total FN	4571

Total Scores
MCC	0.000
Average MCC ± 95% Confidence Intervals	0.000 ± 0.000
Sensitivity	0.000
Positive Predictive Value	0.000
Nr of predictions	48

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00001	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	34191	0	0	0	0	75
ASE_00002	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	73
ASE_00009	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	26106	0	0	0	0	67
ASE_00014	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	106
ASE_00116	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	66
ASE_00120	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46971	0	0	0	0	94
ASE_00121	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	45150	0	0	0	0	92
ASE_00145	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	111
ASE_00148	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112575	0	0	0	0	154
ASE_00154	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	65341	0	0	0	0	107
ASE_00155	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	142
ASE_00187	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	115
ASE_00196	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	31626	0	0	0	0	75
ASE_00205	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	90
ASE_00209	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	43071	0	0	0	0	88
ASE_00210	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	65
ASE_00213	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	27261	0	0	0	0	66
ASE_00222	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	112101	0	0	0	0	157
ASE_00346	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	48205	0	0	0	0	97
ASE_00359	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	42778	0	0	0	0	80
ASE_00360	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	29403	0	0	0	0	65
ASE_00417	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	54615	0	0	0	0	100
ASE_00418	RNaseP_arch links to Rfam database...	0.00	0.00	0.00	0	38781	0	0	0	0	75
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103740	0	0	0	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77421	0	0	0	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34980	0	0	0	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121771	0	0	0	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56280	0	0	0	0	61
CRW_00619	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	165025	0	0	0	0	73
CRW_00620	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	150975	0	0	0	0	63
CRW_00621	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	153181	0	0	0	0	71
CRW_00623	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	129795	0	0	0	0	83
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	0	0	0	0	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70125	0	0	0	0	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72390	0	0	0	0	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	0	0	0	0	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93528	0	0	0	0	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	0	0	0	0	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27028	0	0	0	0	81
RFA_00597	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	97903	0	0	0	0	109
RFA_00598	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	84666	0	0	0	0	101
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00600	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	120295	0	0	0	0	100
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]