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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Cylofold [.zip] - may take several seconds...


Overview

Metric McQFold Cylofold
MCC 0.526 > 0.271
Average MCC ± 95% Confidence Intervals 0.530 ± 1.339 > 0.275 ± 1.303
Sensitivity 0.489 > 0.241
Positive Predictive Value 0.568 > 0.308
Total TP 67 > 33
Total TN 60470 < 60481
Total FP 60 < 78
Total FP CONTRA 6 > 3
Total FP INCONS 45 < 71
Total FP COMP 9 > 4
Total FN 70 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of McQFold and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Cylofold).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 67
Total TN 60470
Total FP 60
Total FP CONTRA 6
Total FP INCONS 45
Total FP COMP 9
Total FN 70
Total Scores
MCC 0.526
Average MCC ± 95% Confidence Intervals 0.530 ± 1.339
Sensitivity 0.489
Positive Predictive Value 0.568
Nr of predictions 2

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.42 0.39 0.46 28 32324 39 3 30 6 43
ASE_00429 - 0.64 0.59 0.68 39 28146 21 3 15 3 27

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 33
Total TN 60481
Total FP 78
Total FP CONTRA 3
Total FP INCONS 71
Total FP COMP 4
Total FN 104
Total Scores
MCC 0.271
Average MCC ± 95% Confidence Intervals 0.275 ± 1.303
Sensitivity 0.241
Positive Predictive Value 0.308
Nr of predictions 2

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.17 0.15 0.20 11 32329 45 3 42 0 60
ASE_00429 - 0.38 0.33 0.43 22 28152 33 0 29 4 44

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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