CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Multilign(20)		NanoFolder
MCC	0.633	>	0.160
Average MCC ± 95% Confidence Intervals	0.632 ± 0.032	>	0.157 ± 0.032
Sensitivity	0.577	>	0.182
Positive Predictive Value	0.696	>	0.142
Total TP	2645	>	837
Total TN	2596307	>	2594232
Total FP	1308	<	5150
Total FP CONTRA	151	<	686
Total FP INCONS	1004	<	4352
Total FP COMP	153	>	112
Total FN	1943	<	3751
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Multilign(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP	2645
Total TN	2596307
Total FP	1308
Total FP CONTRA	151
Total FP INCONS	1004
Total FP COMP	153
Total FN	1943

Total Scores
MCC	0.633
Average MCC ± 95% Confidence Intervals	0.632 ± 0.032
Sensitivity	0.577
Positive Predictive Value	0.696
Nr of predictions	44

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.82	0.74	0.91	81	62392	10	0	8	2	29
ASE_00185	RNaseP_bact_a links to Rfam database...	0.42	0.38	0.47	48	73434	58	2	52	4	80
ASE_00190	RNaseP_bact_b links to Rfam database...	0.46	0.37	0.57	33	45393	28	4	21	3	57
ASE_00221	RNaseP_bact_a links to Rfam database...	0.65	0.56	0.74	66	64531	24	0	23	1	51
ASE_00228	RNaseP_bact_a links to Rfam database...	0.69	0.67	0.72	58	46890	26	4	19	3	28
ASE_00229	RNaseP_bact_a links to Rfam database...	0.60	0.57	0.63	50	42406	32	4	26	2	37
ASE_00231	RNaseP_bact_a links to Rfam database...	0.44	0.40	0.50	38	47819	42	3	35	4	58
ASE_00234	RNaseP_bact_a links to Rfam database...	0.68	0.60	0.76	78	75363	27	6	19	2	51
ASE_00238	RNaseP_bact_a links to Rfam database...	0.50	0.45	0.55	51	64169	42	6	35	1	63
ASE_00254	RNaseP_bact_a links to Rfam database...	0.48	0.46	0.50	38	36780	39	5	33	1	44
ASE_00257	RNaseP_bact_a links to Rfam database...	0.70	0.64	0.78	62	50960	25	1	17	7	35
ASE_00267	RNaseP_bact_a links to Rfam database...	0.75	0.68	0.82	60	45077	21	1	12	8	28
ASE_00270	RNaseP_bact_a links to Rfam database...	0.56	0.49	0.64	63	72292	38	2	33	3	65
ASE_00274	RNaseP_bact_a links to Rfam database...	0.59	0.51	0.67	53	55532	28	5	21	2	50
ASE_00277	RNaseP_bact_a links to Rfam database...	0.79	0.75	0.83	68	48123	16	0	14	2	23
ASE_00279	RNaseP_bact_a links to Rfam database...	0.78	0.73	0.82	74	53211	20	2	14	4	27
ASE_00285	RNaseP_bact_a links to Rfam database...	0.58	0.51	0.67	62	68914	32	3	27	2	60
ASE_00287	RNaseP_bact_a links to Rfam database...	0.62	0.56	0.68	58	54861	28	0	27	1	45
ASE_00294	RNaseP_bact_a links to Rfam database...	0.75	0.63	0.89	108	114359	16	1	13	2	63
ASE_00298	RNaseP_bact_a links to Rfam database...	0.48	0.43	0.53	49	67435	46	2	42	2	64
ASE_00340	RNaseP_bact_a links to Rfam database...	0.58	0.54	0.63	46	45983	31	8	19	4	39
ASE_00367	RNaseP_bact_a links to Rfam database...	0.57	0.53	0.61	46	42995	36	1	29	6	40
ASE_00370	RNaseP_bact_a links to Rfam database...	0.86	0.81	0.92	68	41831	14	0	6	8	16
ASE_00372	RNaseP_bact_a links to Rfam database...	0.67	0.59	0.77	59	51926	19	1	17	1	41
ASE_00376	RNaseP_bact_a links to Rfam database...	0.66	0.61	0.71	64	56863	28	1	25	2	41
ASE_00377	RNaseP_bact_a links to Rfam database...	0.61	0.55	0.69	59	57544	29	3	24	2	48
ASE_00386	RNaseP_bact_a links to Rfam database...	0.65	0.60	0.70	58	50320	27	5	20	2	38
ASE_00393	RNaseP_bact_a links to Rfam database...	0.70	0.63	0.77	59	47818	20	1	17	2	34
ASE_00412	RNaseP_bact_a links to Rfam database...	0.56	0.50	0.62	53	58226	34	3	29	2	52
ASE_00413	RNaseP_bact_a links to Rfam database...	0.60	0.57	0.64	46	44479	27	2	24	1	35
ASE_00416	RNaseP_bact_a links to Rfam database...	0.69	0.59	0.80	75	77327	28	1	18	9	52
ASE_00422	RNaseP_bact_a links to Rfam database...	0.65	0.63	0.67	59	46883	30	4	25	1	35
ASE_00428	RNaseP_bact_a links to Rfam database...	0.57	0.54	0.60	68	76522	47	4	42	1	57
ASE_00430	RNaseP_bact_a links to Rfam database...	0.79	0.76	0.82	74	46881	16	2	14	0	23
ASE_00437	RNaseP_bact_a links to Rfam database...	0.67	0.60	0.75	81	79293	27	1	26	0	54
ASE_00451	RNaseP_bact_a links to Rfam database...	0.68	0.60	0.77	75	70779	24	1	21	2	50
TMR_00123	tmRNA links to Rfam database...	0.64	0.59	0.68	60	66342	34	4	24	6	41
TMR_00399	tmRNA links to Rfam database...	0.48	0.45	0.52	42	64899	46	9	30	7	52
TMR_00443	tmRNA links to Rfam database...	0.67	0.59	0.77	61	67082	22	4	14	4	43
TMR_00469	tmRNA links to Rfam database...	0.75	0.73	0.78	73	64526	30	7	14	9	27
TMR_00519	tmRNA links to Rfam database...	0.60	0.57	0.64	54	63106	34	12	18	4	41
TMR_00528	tmRNA links to Rfam database...	0.51	0.45	0.58	44	63114	37	10	22	5	53
TMR_00571	tmRNA links to Rfam database...	0.69	0.65	0.73	64	60638	34	10	14	10	35
TMR_00584	tmRNA links to Rfam database...	0.65	0.61	0.69	59	60989	36	6	21	9	38

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	837
Total TN	2594232
Total FP	5150
Total FP CONTRA	686
Total FP INCONS	4352
Total FP COMP	112
Total FN	3751

Total Scores
MCC	0.160
Average MCC ± 95% Confidence Intervals	0.157 ± 0.032
Sensitivity	0.182
Positive Predictive Value	0.142
Nr of predictions	44

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.10	0.12	0.08	11	48071	123	23	100	0	80
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00370	RNaseP_bact_a links to Rfam database...	0.03	0.04	0.03	3	41796	109	18	88	3	81
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00377	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	29	57505	98	10	86	2	78
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
TMR_00123	tmRNA links to Rfam database...	0.19	0.23	0.16	23	66283	126	20	104	2	78
TMR_00399	tmRNA links to Rfam database...	0.20	0.26	0.16	24	64833	130	38	85	7	70
TMR_00443	tmRNA links to Rfam database...	0.17	0.20	0.15	21	67018	126	24	98	4	83
TMR_00469	tmRNA links to Rfam database...	0.10	0.12	0.08	12	64469	145	27	112	6	88
TMR_00519	tmRNA links to Rfam database...	0.04	0.05	0.03	5	63046	141	33	106	2	90
TMR_00528	tmRNA links to Rfam database...	0.13	0.15	0.11	15	63051	131	20	104	7	82
TMR_00571	tmRNA links to Rfam database...	0.05	0.06	0.04	6	60577	149	19	124	6	93
TMR_00584	tmRNA links to Rfam database...	0.01	0.01	0.01	1	60922	159	33	119	7	96

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

2. Individual counts for Multilign(20) [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]