CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(20)		NanoFolder
MCC	0.539	>	0.151
Average MCC ± 95% Confidence Intervals	0.539 ± 0.042	>	0.151 ± 0.032
Sensitivity	0.402	>	0.174
Positive Predictive Value	0.723	>	0.134
Total TP	1725	>	745
Total TN	2495022	>	2491851
Total FP	722	<	4907
Total FP CONTRA	77	<	654
Total FP INCONS	584	<	4158
Total FP COMP	61	<	95
Total FN	2564	<	3544
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Murlet(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP	1725
Total TN	2495022
Total FP	722
Total FP CONTRA	77
Total FP INCONS	584
Total FP COMP	61
Total FN	2564

Total Scores
MCC	0.539
Average MCC ± 95% Confidence Intervals	0.539 ± 0.042
Sensitivity	0.402
Positive Predictive Value	0.723
Nr of predictions	40

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.54	0.39	0.75	43	62424	14	2	12	0	67
ASE_00185	RNaseP_bact_a links to Rfam database...	0.28	0.16	0.48	21	73492	23	0	23	0	107
ASE_00190	RNaseP_bact_b links to Rfam database...	0.38	0.22	0.67	20	45421	12	0	10	2	70
ASE_00221	RNaseP_bact_a links to Rfam database...	0.58	0.44	0.78	51	64555	14	0	14	0	66
ASE_00228	RNaseP_bact_a links to Rfam database...	0.53	0.44	0.63	38	46911	23	1	21	1	48
ASE_00229	RNaseP_bact_a links to Rfam database...	0.61	0.48	0.76	42	42431	13	3	10	0	45
ASE_00238	RNaseP_bact_a links to Rfam database...	0.45	0.30	0.68	34	64211	16	2	14	0	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.76	0.63	0.91	72	62402	7	0	7	0	42
ASE_00255	RNaseP_bact_a links to Rfam database...	0.53	0.39	0.72	51	74620	21	1	19	1	79
ASE_00257	RNaseP_bact_a links to Rfam database...	0.55	0.43	0.69	42	50979	19	0	19	0	55
ASE_00267	RNaseP_bact_a links to Rfam database...	0.76	0.61	0.95	54	45093	4	2	1	1	34
ASE_00270	RNaseP_bact_a links to Rfam database...	0.21	0.14	0.32	18	72333	41	0	39	2	110
ASE_00279	RNaseP_bact_a links to Rfam database...	0.63	0.48	0.84	48	53244	9	1	8	0	53
ASE_00285	RNaseP_bact_a links to Rfam database...	0.45	0.33	0.62	40	68941	25	1	24	0	82
ASE_00294	RNaseP_bact_a links to Rfam database...	0.55	0.37	0.83	63	114405	14	4	9	1	108
ASE_00298	RNaseP_bact_a links to Rfam database...	0.22	0.15	0.32	17	67475	36	4	32	0	96
ASE_00318	RNaseP_bact_b links to Rfam database...	0.66	0.49	0.89	58	80135	16	2	5	9	60
ASE_00335	RNaseP_bact_b links to Rfam database...	0.60	0.48	0.76	56	75392	19	5	13	1	60
ASE_00340	RNaseP_bact_a links to Rfam database...	0.45	0.34	0.60	29	46008	22	3	16	3	56
ASE_00367	RNaseP_bact_a links to Rfam database...	0.71	0.57	0.89	49	43016	6	2	4	0	37
ASE_00372	RNaseP_bact_a links to Rfam database...	0.40	0.31	0.53	31	51944	28	3	25	0	69
ASE_00376	RNaseP_bact_a links to Rfam database...	0.57	0.40	0.82	42	56902	9	2	7	0	63
ASE_00386	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.80	35	50359	9	1	8	0	61
ASE_00393	RNaseP_bact_a links to Rfam database...	0.55	0.41	0.73	38	47843	15	3	11	1	55
ASE_00412	RNaseP_bact_a links to Rfam database...	0.51	0.32	0.79	34	58268	11	0	9	2	71
ASE_00416	RNaseP_bact_a links to Rfam database...	0.45	0.33	0.62	42	77353	26	1	25	0	85
ASE_00422	RNaseP_bact_a links to Rfam database...	0.50	0.35	0.70	33	46924	14	0	14	0	61
ASE_00428	RNaseP_bact_a links to Rfam database...	0.47	0.34	0.67	42	76573	21	4	17	0	83
ASE_00430	RNaseP_bact_a links to Rfam database...	0.50	0.37	0.68	36	46918	17	0	17	0	61
ASE_00437	RNaseP_bact_a links to Rfam database...	0.42	0.32	0.56	43	79324	34	3	31	0	92
ASE_00451	RNaseP_bact_a links to Rfam database...	0.56	0.41	0.76	51	70809	16	1	15	0	74
TMR_00123	tmRNA links to Rfam database...	0.64	0.50	0.81	51	66367	17	3	9	5	50
TMR_00399	tmRNA links to Rfam database...	0.61	0.47	0.79	44	64924	18	2	10	6	50
TMR_00443	tmRNA links to Rfam database...	0.73	0.61	0.88	63	67089	13	0	9	4	41
TMR_00469	tmRNA links to Rfam database...	0.64	0.48	0.84	48	64563	10	3	6	1	52
TMR_00519	tmRNA links to Rfam database...	0.49	0.37	0.65	35	63136	23	2	17	4	60
TMR_00528	tmRNA links to Rfam database...	0.48	0.41	0.57	40	63120	36	7	23	6	57
TMR_00571	tmRNA links to Rfam database...	0.76	0.67	0.86	66	60649	15	2	9	4	33
TMR_00584	tmRNA links to Rfam database...	0.71	0.62	0.81	60	61001	17	4	10	3	37
TMR_00703	tmRNA links to Rfam database...	0.58	0.45	0.75	45	67468	19	3	12	4	54

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	745
Total TN	2491851
Total FP	4907
Total FP CONTRA	654
Total FP INCONS	4158
Total FP COMP	95
Total FN	3544

Total Scores
MCC	0.151
Average MCC ± 95% Confidence Intervals	0.151 ± 0.032
Sensitivity	0.174
Positive Predictive Value	0.134
Nr of predictions	40

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.13	0.15	0.12	17	62340	124	9	115	0	97
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00318	RNaseP_bact_b links to Rfam database...	0.03	0.04	0.03	5	80039	156	21	135	0	113
ASE_00335	RNaseP_bact_b links to Rfam database...	0.10	0.12	0.09	14	75304	151	22	126	3	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
TMR_00123	tmRNA links to Rfam database...	0.19	0.23	0.16	23	66283	126	20	104	2	78
TMR_00399	tmRNA links to Rfam database...	0.20	0.26	0.16	24	64833	130	38	85	7	70
TMR_00443	tmRNA links to Rfam database...	0.17	0.20	0.15	21	67018	126	24	98	4	83
TMR_00469	tmRNA links to Rfam database...	0.10	0.12	0.08	12	64469	145	27	112	6	88
TMR_00519	tmRNA links to Rfam database...	0.04	0.05	0.03	5	63046	141	33	106	2	90
TMR_00528	tmRNA links to Rfam database...	0.13	0.15	0.11	15	63051	131	20	104	7	82
TMR_00571	tmRNA links to Rfam database...	0.05	0.06	0.04	6	60577	149	19	124	6	93
TMR_00584	tmRNA links to Rfam database...	0.01	0.01	0.01	1	60922	159	33	119	7	96
TMR_00703	tmRNA links to Rfam database...	0.10	0.12	0.08	12	67376	140	26	114	0	87

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

2. Individual counts for Murlet(20) [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]