CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric Murlet(20) RNAalifold(seed)
MCC 0.533 > 0.456
Average MCC ± 95% Confidence Intervals 0.534 ± 0.025 > 0.448 ± 0.018
Sensitivity 0.389 > 0.260
Positive Predictive Value 0.732 < 0.802
Total TP 4397 > 2944
Total TN 6436955 < 6439294
Total FP 1732 > 778
Total FP CONTRA 147 > 111
Total FP INCONS 1464 > 614
Total FP COMP 121 > 53
Total FN 6918 < 8371
P-value 3.56938820447e-08

^top




Performance plots


  1. Comparison of performance of Murlet(20) and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNAalifold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNAalifold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNAalifold(seed)).

^top





Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 4397
Total TN 6436955
Total FP 1732
Total FP CONTRA 147
Total FP INCONS 1464
Total FP COMP 121
Total FN 6918
Total Scores
MCC 0.533
Average MCC ± 95% Confidence Intervals 0.534 ± 0.025
Sensitivity 0.389
Positive Predictive Value 0.732
Nr of predictions 106

^top



2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.46 0.34 0.61 33 47841 21 1 20 0 64
ASE_00007 0.71 0.57 0.89 63 59614 8 2 6 0 47
ASE_00018 0.61 0.45 0.82 60 80528 13 3 10 0 74
ASE_00022 0.67 0.50 0.89 62 82958 15 0 8 7 62
ASE_00028 0.56 0.40 0.77 51 84600 15 5 10 0 75
ASE_00035 0.62 0.49 0.79 58 70427 17 4 11 2 60
ASE_00040 0.62 0.43 0.90 57 78940 6 0 6 0 76
ASE_00064 0.55 0.39 0.76 35 45405 14 3 8 3 54
ASE_00068 0.62 0.42 0.90 36 37635 4 3 1 0 49
ASE_00075 0.51 0.34 0.76 55 108739 19 1 16 2 107
ASE_00077 0.48 0.35 0.67 30 45105 18 0 15 3 56
ASE_00078 0.64 0.53 0.79 44 43015 12 3 9 0 39
ASE_00080 0.31 0.21 0.46 26 71574 31 3 28 0 97
ASE_00081 0.73 0.58 0.93 56 49710 5 0 4 1 41
ASE_00082 0.27 0.20 0.37 23 70438 42 2 37 3 93
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00084 0.53 0.36 0.77 36 53581 12 0 11 1 63
ASE_00087 0.35 0.21 0.58 30 88358 22 0 22 0 114
ASE_00092 0.58 0.40 0.85 45 63493 10 0 8 2 68
ASE_00104 0.51 0.38 0.69 45 64196 20 1 19 0 74
ASE_00107 0.64 0.48 0.86 61 73082 13 2 8 3 66
ASE_00115 0.46 0.30 0.71 30 54573 12 1 11 0 71
ASE_00119 0.11 0.08 0.16 9 62779 48 2 45 1 99
ASE_00123 0.55 0.40 0.76 34 38458 11 0 11 0 51
ASE_00135 0.34 0.24 0.49 26 63137 29 3 24 2 83
ASE_00138 0.60 0.47 0.76 38 40420 13 0 12 1 43
ASE_00142 0.52 0.40 0.68 49 67089 23 1 22 0 73
ASE_00146 0.70 0.56 0.87 69 70797 13 0 10 3 55
ASE_00153 0.34 0.23 0.50 17 57596 26 3 14 9 56
ASE_00163 0.47 0.32 0.70 30 53258 13 0 13 0 63
ASE_00170 0.52 0.37 0.74 34 48782 12 0 12 0 59
ASE_00174 0.30 0.23 0.39 25 61011 43 2 37 4 84
ASE_00179 0.49 0.40 0.61 34 44197 22 0 22 0 50
ASE_00180 0.70 0.55 0.90 55 51299 6 2 4 0 45
ASE_00182 0.24 0.15 0.41 20 84206 31 1 28 2 116
ASE_00184 0.58 0.42 0.80 43 54561 11 2 9 0 59
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00186 0.61 0.45 0.84 59 78933 11 1 10 0 73
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00212 0.55 0.39 0.78 58 93887 16 1 15 0 90
ASE_00214 0.40 0.27 0.58 28 56232 21 1 19 1 75
ASE_00215 0.46 0.31 0.69 31 48471 14 4 10 0 68
ASE_00217 0.66 0.50 0.87 45 40418 7 1 6 0 45
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00241 0.66 0.55 0.79 48 43895 16 2 11 3 39
ASE_00248 0.76 0.63 0.91 72 62402 7 0 7 0 42
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00280 0.67 0.54 0.84 53 51940 10 3 7 0 45
ASE_00281 0.74 0.60 0.91 53 44493 5 0 5 0 35
ASE_00283 0.55 0.41 0.73 44 61716 16 0 16 0 63
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00292 0.52 0.36 0.74 50 81742 18 1 17 0 88
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00297 0.59 0.41 0.85 40 52928 10 0 7 3 58
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00318 0.66 0.49 0.89 58 80135 16 2 5 9 60
ASE_00328 0.59 0.48 0.72 54 72696 27 5 16 6 58
ASE_00332 0.63 0.47 0.83 65 81732 13 2 11 0 73
ASE_00335 0.60 0.48 0.76 56 75392 19 5 13 1 60
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00353 0.50 0.35 0.71 37 57918 15 0 15 0 70
ASE_00361 0.57 0.39 0.82 50 75405 11 1 10 0 77
ASE_00362 0.56 0.38 0.81 35 48162 12 0 8 4 56
ASE_00363 0.61 0.44 0.85 41 51312 7 0 7 0 53
ASE_00364 0.58 0.38 0.89 40 54240 5 0 5 0 65
ASE_00366 0.49 0.36 0.67 35 58601 19 0 17 2 63
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00382 0.65 0.51 0.83 43 41853 9 2 7 0 41
ASE_00384 0.59 0.43 0.80 40 48466 10 2 8 0 52
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00387 0.64 0.45 0.90 47 55893 5 0 5 0 57
ASE_00388 0.53 0.38 0.72 34 45706 16 1 12 3 55
ASE_00390 0.77 0.64 0.93 54 42137 6 1 3 2 31
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00394 0.56 0.41 0.78 38 46922 11 1 10 0 55
ASE_00395 0.68 0.51 0.90 43 41568 5 0 5 0 41
ASE_00396 0.62 0.47 0.81 39 41568 9 0 9 0 44
ASE_00397 0.63 0.45 0.89 47 54562 9 1 5 3 58
ASE_00398 0.49 0.32 0.75 33 55901 12 0 11 1 71
ASE_00400 0.47 0.36 0.61 38 57908 25 3 21 1 68
ASE_00402 0.55 0.35 0.86 30 42451 5 2 3 0 55
ASE_00404 0.72 0.55 0.94 47 43021 4 0 3 1 38
ASE_00406 0.60 0.44 0.84 41 48779 8 0 8 0 53
ASE_00411 0.59 0.39 0.88 35 49415 5 0 5 0 54
ASE_00412 0.51 0.32 0.79 34 58268 11 0 9 2 71
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00419 0.49 0.33 0.74 34 54900 12 2 10 0 69
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00423 0.65 0.53 0.79 58 56880 15 0 15 0 51
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00448 0.63 0.49 0.82 55 64194 12 3 9 0 57
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
RFA_00599 0.44 0.34 0.58 38 101409 33 1 27 5 73
RFA_00601 0.31 0.23 0.42 26 99173 43 3 33 7 88
RFA_00602 0.24 0.16 0.35 19 101421 41 2 33 6 97

^top



Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 2944
Total TN 6439294
Total FP 778
Total FP CONTRA 111
Total FP INCONS 614
Total FP COMP 53
Total FN 8371
Total Scores
MCC 0.456
Average MCC ± 95% Confidence Intervals 0.448 ± 0.018
Sensitivity 0.260
Positive Predictive Value 0.802
Nr of predictions 106

^top



2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.45 0.23 0.88 22 47870 3 0 3 0 75
ASE_00007 0.52 0.33 0.82 36 59641 8 1 7 0 74
ASE_00018 0.47 0.27 0.82 36 80557 8 1 7 0 98
ASE_00022 0.65 0.48 0.89 59 82962 13 1 6 6 65
ASE_00028 0.65 0.48 0.90 60 84599 12 1 6 5 66
ASE_00035 0.47 0.28 0.80 33 70459 11 1 7 3 85
ASE_00040 0.47 0.27 0.82 36 78959 8 1 7 0 97
ASE_00064 0.44 0.25 0.79 22 45423 6 1 5 0 67
ASE_00068 0.37 0.20 0.68 17 37650 8 1 7 0 68
ASE_00075 0.38 0.19 0.79 30 108773 13 1 7 5 132
ASE_00077 0.40 0.21 0.75 18 45126 6 1 5 0 68
ASE_00078 0.49 0.28 0.85 23 43044 6 0 4 2 60
ASE_00080 0.23 0.11 0.48 14 71602 15 1 14 0 109
ASE_00081 0.43 0.24 0.79 23 49741 6 1 5 0 74
ASE_00082 0.34 0.16 0.75 18 70476 6 1 5 0 98
ASE_00083 0.41 0.21 0.79 23 62452 6 1 5 0 87
ASE_00084 0.43 0.23 0.79 23 53599 6 1 5 0 76
ASE_00087 0.36 0.16 0.79 23 88381 6 1 5 0 121
ASE_00092 0.40 0.20 0.79 23 63517 6 1 5 0 90
ASE_00104 0.50 0.30 0.82 36 64217 8 1 7 0 83
ASE_00107 0.48 0.28 0.82 36 73109 8 1 7 0 91
ASE_00115 0.41 0.22 0.79 22 54587 6 1 5 0 79
ASE_00119 0.31 0.12 0.81 13 62819 3 1 2 0 95
ASE_00123 0.38 0.20 0.74 17 38480 6 1 5 0 68
ASE_00135 0.37 0.19 0.72 21 63161 8 1 7 0 88
ASE_00138 0.47 0.28 0.79 23 40441 6 1 5 0 58
ASE_00142 0.50 0.30 0.84 36 67118 7 1 6 0 86
ASE_00146 0.49 0.29 0.82 36 70832 8 1 7 0 88
ASE_00153 0.37 0.21 0.68 15 57608 7 0 7 0 58
ASE_00163 0.44 0.25 0.79 23 53272 6 1 5 0 70
ASE_00170 0.44 0.25 0.79 23 48799 6 1 5 0 70
ASE_00174 0.39 0.20 0.76 22 61046 7 2 5 0 87
ASE_00179 0.39 0.20 0.77 17 44231 5 1 4 0 67
ASE_00180 0.42 0.23 0.77 23 51330 7 2 5 0 77
ASE_00182 0.37 0.17 0.79 23 84226 6 1 5 0 113
ASE_00184 0.42 0.23 0.79 23 54586 6 1 5 0 79
ASE_00185 0.38 0.18 0.79 23 73507 6 1 5 0 105
ASE_00186 0.43 0.25 0.75 33 78959 11 1 10 0 99
ASE_00190 0.66 0.50 0.87 45 45399 12 1 6 5 45
ASE_00212 0.40 0.22 0.74 32 93918 11 1 10 0 116
ASE_00214 0.35 0.17 0.72 18 56255 7 2 5 0 85
ASE_00215 0.36 0.17 0.74 17 48493 6 1 5 0 82
ASE_00217 0.51 0.33 0.79 30 40432 8 1 7 0 60
ASE_00221 0.50 0.31 0.82 36 64576 8 1 7 0 81
ASE_00228 0.47 0.26 0.88 22 46946 3 0 3 0 64
ASE_00229 0.47 0.25 0.88 22 42461 3 0 3 0 65
ASE_00238 0.38 0.19 0.73 22 64231 8 3 5 0 92
ASE_00241 0.46 0.26 0.79 23 43927 6 1 5 0 64
ASE_00248 0.51 0.32 0.82 36 62437 8 1 7 0 78
ASE_00255 0.47 0.27 0.81 35 74648 8 1 7 0 95
ASE_00257 0.43 0.24 0.79 23 51011 6 1 5 0 74
ASE_00267 0.45 0.26 0.79 23 45121 6 1 5 0 65
ASE_00270 0.22 0.09 0.52 12 72367 12 1 10 1 116
ASE_00279 0.42 0.23 0.79 23 53272 6 1 5 0 78
ASE_00280 0.40 0.18 0.86 18 51982 3 1 2 0 80
ASE_00281 0.45 0.26 0.79 23 44522 6 1 5 0 65
ASE_00283 0.35 0.17 0.75 18 61752 6 1 5 0 89
ASE_00285 0.39 0.19 0.79 23 68977 6 1 5 0 99
ASE_00292 0.46 0.26 0.82 36 81766 8 1 7 0 102
ASE_00294 0.41 0.21 0.82 36 114437 8 1 7 0 135
ASE_00297 0.43 0.23 0.79 23 52946 6 1 5 0 75
ASE_00298 0.40 0.20 0.79 23 67499 6 1 5 0 90
ASE_00318 0.66 0.48 0.89 57 80136 13 1 6 6 61
ASE_00328 0.69 0.54 0.90 60 72704 12 1 6 5 52
ASE_00332 0.46 0.26 0.82 36 81766 8 1 7 0 102
ASE_00335 0.68 0.52 0.90 60 75399 12 1 6 5 56
ASE_00340 0.43 0.21 0.86 18 46035 3 0 3 0 67
ASE_00353 0.41 0.21 0.77 23 57940 7 2 5 0 84
ASE_00361 0.36 0.17 0.76 22 75437 7 2 5 0 105
ASE_00362 0.45 0.25 0.79 23 48176 6 1 5 0 68
ASE_00363 0.44 0.24 0.79 23 51331 6 1 5 0 71
ASE_00364 0.41 0.22 0.77 23 54255 7 2 5 0 82
ASE_00366 0.36 0.18 0.72 18 58628 7 2 5 0 80
ASE_00367 0.46 0.27 0.79 23 43042 6 1 5 0 63
ASE_00372 0.41 0.22 0.76 22 51974 7 1 6 0 78
ASE_00376 0.42 0.22 0.79 23 56924 6 1 5 0 82
ASE_00382 0.47 0.27 0.79 23 41876 6 1 5 0 61
ASE_00384 0.44 0.25 0.79 23 48487 6 1 5 0 69
ASE_00386 0.44 0.24 0.79 23 50374 6 1 5 0 73
ASE_00387 0.38 0.20 0.72 21 55916 8 1 7 0 83
ASE_00388 0.45 0.26 0.79 23 45724 6 1 5 0 66
ASE_00390 0.46 0.27 0.79 23 42166 6 1 5 0 62
ASE_00393 0.40 0.23 0.72 21 47866 8 1 7 0 72
ASE_00394 0.44 0.25 0.79 23 46942 6 1 5 0 70
ASE_00395 0.47 0.27 0.79 23 41587 6 1 5 0 61
ASE_00396 0.47 0.28 0.79 23 41587 6 1 5 0 60
ASE_00397 0.42 0.22 0.79 23 54586 6 1 5 0 82
ASE_00398 0.42 0.22 0.79 23 55916 6 1 5 0 81
ASE_00400 0.41 0.22 0.79 23 57941 6 1 5 0 83
ASE_00402 0.46 0.27 0.79 23 42457 6 1 5 0 62
ASE_00404 0.46 0.27 0.79 23 43042 6 1 5 0 62
ASE_00406 0.44 0.24 0.79 23 48799 6 1 5 0 71
ASE_00411 0.41 0.25 0.69 22 49423 10 5 5 0 67
ASE_00412 0.39 0.21 0.73 22 58281 8 3 5 0 83
ASE_00416 0.47 0.28 0.80 35 77377 9 1 8 0 92
ASE_00419 0.40 0.21 0.73 22 54916 8 2 6 0 81
ASE_00422 0.40 0.19 0.86 18 46950 3 0 3 0 76
ASE_00423 0.51 0.32 0.81 35 56910 8 1 7 0 74
ASE_00428 0.47 0.28 0.80 35 76592 9 1 8 0 90
ASE_00430 0.41 0.21 0.83 20 46947 4 0 4 0 77
ASE_00437 0.30 0.17 0.55 23 79359 19 1 18 0 112
ASE_00448 0.48 0.30 0.77 34 64217 10 1 9 0 78
ASE_00451 0.48 0.29 0.82 36 70832 8 1 7 0 89
RFA_00599 0.79 0.66 0.95 73 101398 7 0 4 3 38
RFA_00601 0.79 0.67 0.93 76 99153 10 0 6 4 38
RFA_00602 0.76 0.65 0.90 75 101392 11 0 8 3 41

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.