CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	PknotsRG		CMfinder(seed)
MCC	0.503	>	0.350
Average MCC ± 95% Confidence Intervals	0.483 ± 0.117	>	0.358 ± 0.060
Sensitivity	0.510	>	0.159
Positive Predictive Value	0.496	<	0.770
Total TP	750	>	234
Total TN	1035139	<	1036346
Total FP	914	>	77
Total FP CONTRA	175	>	3
Total FP INCONS	586	>	67
Total FP COMP	153	>	7
Total FN	720	<	1236
P-value	1.89649746203e-08

Comparison of performance of PknotsRG and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).

Total Scores
MCC	0.503
Average MCC ± 95% Confidence Intervals	0.483 ± 0.117
Sensitivity	0.510
Positive Predictive Value	0.496
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.16	0.17	0.15	19	103617	114	25	79	10	96
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.66	74	77309	50	5	33	12	46
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.49	0.49	40	36233	43	7	35	1	41
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.59	0.69	46	34913	29	1	20	8	32
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.11	0.07	6	121690	145	21	54	70	51
CRW_00618	Intron_gpI links to Rfam database...	0.11	0.11	0.10	7	56211	83	13	49	21	54
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.48	0.52	51	63447	50	10	38	2	55
CRW_00634	Intron_gpI links to Rfam database...	0.56	0.60	0.52	56	64513	53	17	34	2	38
CRW_00670	Intron_gpI links to Rfam database...	0.75	0.74	0.77	89	70009	30	5	22	3	31
CRW_00671	Intron_gpI links to Rfam database...	0.77	0.76	0.78	89	62721	30	6	19	5	28
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.55	0.52	61	72273	60	21	35	4	50
CRW_00674	Intron_gpI links to Rfam database...	0.52	0.52	0.52	65	83310	63	12	49	2	59
CRW_00676	Intron_gpI links to Rfam database...	0.56	0.60	0.52	69	93396	67	13	50	4	46
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.41	41	68536	66	18	40	8	49
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44

Total Scores
MCC	0.350
Average MCC ± 95% Confidence Intervals	0.358 ± 0.060
Sensitivity	0.159
Positive Predictive Value	0.770
Nr of predictions	15

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.