CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASLOpt		CMfinder(seed)
MCC	0.450	>	0.356
Average MCC ± 95% Confidence Intervals	0.446 ± 0.126	>	0.364 ± 0.066
Sensitivity	0.424	>	0.168
Positive Predictive Value	0.480	<	0.757
Total TP	449	>	178
Total TN	633240	<	633940
Total FP	539	>	57
Total FP CONTRA	73	>	2
Total FP INCONS	413	>	55
Total FP COMP	53	>	0
Total FN	610	<	881
P-value	1.22797000563e-08

Comparison of performance of RNASLOpt and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).

Total Scores
MCC	0.450
Average MCC ± 95% Confidence Intervals	0.446 ± 0.126
Sensitivity	0.424
Positive Predictive Value	0.480
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.52	54	77317	58	5	45	8	66
CRW_00610	Intron_gpI links to Rfam database...	0.06	0.06	0.07	5	36246	64	9	55	0	76
CRW_00613	Intron_gpI links to Rfam database...	0.59	0.50	0.70	39	34924	24	1	16	7	39
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	62	6	43	13	48
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.49	0.51	52	63444	52	5	45	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.50	0.51	47	64527	48	11	35	2	47
CRW_00670	Intron_gpI links to Rfam database...	0.45	0.43	0.47	52	70015	58	8	50	0	68
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.53	0.68	62	62744	32	2	27	3	55
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.41	0.45	45	72291	57	6	48	3	66
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.33	31	68540	77	20	44	13	59
PDB_00827	Intron_gpI links to Rfam database...	0.74	0.60	0.91	49	26974	7	0	5	2	32

Total Scores
MCC	0.356
Average MCC ± 95% Confidence Intervals	0.364 ± 0.066
Sensitivity	0.168
Positive Predictive Value	0.757
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.